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Table 3 Cox proportional hazards model

From: ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma

A Lymph node metastasis
Variable B SE Wald P OR 95% CI for OR
Lower limit Upper limit
High-ITGA3/CD9 1.063 0.203 27.545 0.000 2.896 1.947 4.307
YK41 0.961 0.216 19.887 0.000 2.614 1.714 3.989
Size2 0.622 0.186 11.126 0.001 1.862 1.292 2.684
B Primary site recurrence
Variable B SE Wald P OR 95% CI for OR
Lower limit Upper limit
High-ITGA3/CD9 1.090 0.415 6.895 0.009 2.973 1.318 6.706
T3-43 0.955 0.387 6.088 0.014 2.597 1.217 5.544
Positive margin4 1.715 0.402 18.183 0.000 5.556 2.526 12.221
C Distant metastasis
Variable B SE Wald P OR 95% CI for OR
Lower limit Upper limit
High-ITGB4/JUP 2.311 0.771 8.990 0.003 10.088 2.227 45.704
High-ITGA3/CD9 2.108 1.047 4.051 0.044 8.233 1.057 64.135
D Death outcome 5
Variable B SE Wald P OR 95% CI for OR
Lower limit Upper limit
High-ITGA3/CD9 1.618 0.450 12.947 0.000 5.041 2.089 12.166
YK4 2.355 0.613 14.743 0.000 10.540 3.168 35.074
Positive margin 1.906 0.398 22.954 0.000 6.725 3.084 14.665
  1. Cox Proportional Hazards Model for the risks of lymph node metastasis, primary site recurrence, distant metastasis, and OSCC death. 14c or 4d of the histopathologic classification of oral squamous cell carcinoma according to Yamamoto et al., 1983 (10). 2Major width of the tumor was categorized into >30 mm and ≤30 mm. 3 T3 to T4 of tumor (T) category according to the International Union Against Cancer (UICC) TNM classification of malignant tumors of the lip and oral cavity. 4Histological tumor positive of the surgical margin. 5Death outcome from uncontrollable oral squamous cell carcinoma. Continuous variables of gene expression ratios are categorized according to the cut off points introduced by receiver operating characteristic curves. Median of ITGA3/CD9 and higher 30% group of ITGB4/JUP are used for categorization. B, regression coefficient; SE, standard error; OR, odds ratio; 95% CI, 95% confidence interval.