ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma

Table 3 Cox proportional hazards model

Cox Proportional Hazards Model for the risks of lymph node metastasis, primary site recurrence, distant metastasis, and OSCC death. ¹4c or 4d of the histopathologic classification of oral squamous cell carcinoma according to Yamamoto et al., 1983 (10). ²Major width of the tumor was categorized into >30 mm and ≤30 mm. ³ T3 to T4 of tumor (T) category according to the International Union Against Cancer (UICC) TNM classification of malignant tumors of the lip and oral cavity. ⁴Histological tumor positive of the surgical margin. ⁵Death outcome from uncontrollable oral squamous cell carcinoma. Continuous variables of gene expression ratios are categorized according to the cut off points introduced by receiver operating characteristic curves. Median of ITGA3/CD9 and higher 30% group of ITGB4/JUP are used for categorization. B, regression coefficient; SE, standard error; OR, odds ratio; 95% CI, 95% confidence interval.

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