ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma

Table 2 Logrank test (Mantel-Cox)

	Lymph node metastasis	Primary site recurrence	Distant metastasis	OSCC death ⁷
Gene expression ratio
High-ITGA3/CD9	0.000	0.005	0.001	0.000
High-ITGB4/JUP	0.022	0.237	0.000	0.001
Clinicopathological parameter
Age¹	0.449	0.321	0.207	0.365
Sex	0.417	0.858	0.149	0.584
Size²	0.000	0.007	0.703	0.084
T3-4³	0.000	0.000	0.390	0.092
YK4⁴	0.000	0.018	0.001	0.000
Positive margin⁵	------	0.000	0.427	0.000
Clinical event
Lymph node metastasis⁶	------	0.001	0.000	0.000
Primary site recurrence	------	------	0.840	0.000
Distant metastasis	------	------	------	0.000

Numbers in the table show P-values for the parameters. ¹Age was categorized into two groups ≥69 and <69 based on the median age. ²Major width of the tumor was categorized into >30 mm and ≤30 mm. ³ T3 to T4 of tumor (T) category according to the International Union Against Cancer (UICC) TNM classification of malignant tumors of the lip and oral cavity. ⁴4c or 4d of the histopathologic classification of oral squamous cell carcinoma according to Yamamoto et al., 1983 (10). ⁵Histological tumor positive of the surgical margin. ⁶Determined by pathologic examination of a surgical specimen. ⁷Death outcome from oral squamous cell carcinoma. Continuous variables of gene expression ratios are categorized according to the cut off points introduced by receiver operating characteristic curves. Median of ITGA3/CD9 and higher 30% group of ITGB4/JUP are used for categorization.

ISSN: 1471-2407