Table 1 IC50 values for NVP-AEW541, PI3K and MAPKK inhibitors in pancreatic cancer cell lines as assessed by the SRB colorimetric assay

BxPc-3

 1.54 (1.37–1.74) μM

  3.5 (2.77–4.1) μM

  6.9 (6.12–7.96) μM

AsPc-1

0.897 (0.79–0.92) μM

 4.9 (4.52–5.42) μM

  5.5 (5.12–6.06) μM

FA-6

0.342 (0.26–0.36) μM

11.5 (10.15–13.08) μM

  9.1 (8.53–9.74) μM

PANC-1

  2.66 (1.8–3.2) μM

 13.7 (12.38–15.2) μM

11.3 (10.28–12.59) μM

Capan-1

 0.969 (0.9–1.04) μM

  2.3 (2.23–2.51) μM

  5.9 (5.56–6.39) μM

MiaPaca-2

 1.13 (1.01–1.38) μM

  3.5 (3.08–4.05) μM

   6 (5.69–6.5) μM

PT45

 2.73 (2.57–2.87) μM

  7.7 (6.97–8.53) μM

   8 (7.54–8.52) μM