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Table 1 IC50 values for NVP-AEW541, PI3K and MAPKK inhibitors in pancreatic cancer cell lines as assessed by the SRB colorimetric assay

From: Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells

ICell line NVPAEW541 MAPKK inh PI3K inh
BxPc-3  1.54 (1.37–1.74) μM   3.5 (2.77–4.1) μM   6.9 (6.12–7.96) μM
AsPc-1 0.897 (0.79–0.92) μM  4.9 (4.52–5.42) μM   5.5 (5.12–6.06) μM
FA-6 0.342 (0.26–0.36) μM 11.5 (10.15–13.08) μM   9.1 (8.53–9.74) μM
PANC-1   2.66 (1.8–3.2) μM  13.7 (12.38–15.2) μM 11.3 (10.28–12.59) μM
Capan-1  0.969 (0.9–1.04) μM   2.3 (2.23–2.51) μM   5.9 (5.56–6.39) μM
MiaPaca-2  1.13 (1.01–1.38) μM   3.5 (3.08–4.05) μM    6 (5.69–6.5) μM
PT45  2.73 (2.57–2.87) μM   7.7 (6.97–8.53) μM    8 (7.54–8.52) μM