MC1Rgenotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: an Australian case-control-family study

Table 5 Odds ratios for melanoma associated with MC1R , nevi and non-melanoma skin cancer

Predictor	Cases	Controls	Minimally-adjusted odds ratio¹(95% CI)	Multivariate-adjusted odds ratio²(95% CI)
MC1R ³
Wild-type consensus alleles only	62	76	1.00	1.00
r only alleles	112	83	1.86 (1.16, 2.96)	1.72 (1.02, 2.89)
Any R allele	239	104	2.91 (1.88, 4.50)	2.94 (1.80, 4.80)
Number of physician-measured nevi ≥ 2 mm⁴
Per 10 nevi increase	413	263	1.08 (1.06, 1.09)	1.08 (1.06, 1.10)
Self-reported nevi categories
None	19	18	1.00	1.00
Few	113	135	0.68 (0.33, 1.42)	0.70 (0.32, 1.50)
Some	184	82	1.78 (0.85, 3.71)	2.01 (0.93, 4.36)
Many	97	28	2.71 (1.21, 6.10)	2.87 (1.23, 6.70)
Previous non-melanoma skin cancer
No	382	259	1.00	1.00
Yes	31	4	8.84 (2.83, 27.63)	8.59 (2.68, 27.47)

¹ Adjusted for age, sex, city of recruitment, and European ancestry.
² Adjusted for age, sex, city of recruitment, European ancestry and other variables in the table (except nevi variables not adjusted for each other).
³ The categories are mutually exclusive. Silent changes (i.e. changes that are synonymous or occur in non-coding regions) are counted as consensus alleles.
⁴ Counted by a dermatology trainee.

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