Table 2 Univariate analysis of correlation of clinical variables with survival, disease progression, and response
Covariate | OS | TTP | OS from recurrence | Response at 3 months | Response at 6 months | Best response |
|---|---|---|---|---|---|---|
(HR) [95% CI] | (HR) [95% CI] | (HR) [95% CI] | (OR) [95% CI] | (OR) [95% CI] | (OR) [95% CI] | |
Operation | ||||||
Gross total vs. biopsy | 0.76 (0.49–1.17) | 0.74 (0.48–1.16) | 0.81 (0.51–1.27) | 4.33 (0.54–35) | 1.88 (0.21–16.9) | 4.00 (0.49–32) |
Partial vs. biopsy | 0.98 (0.64–1.50) | 0.86 (0.56–1.32) | 1.05 (0.68–1.65) | 1.37 (0.15–12.2) | 0.86 (0.09–8.22) | 2.13 (0.25–17) |
P = .22 | P = .37 | P = .23 | P = .07 | P = .35 | P = .24 | |
Age (per 10-year increase) | 1.36 (1.17–1.58) | 1.17 (1.01–1.36) | 1.36 (1.16–1.60) | 0.66 (0.43–1.01) | 0.76 (0.46–1.23) | 0.66 (0.44–0.99) |
P < .0001 | P = .034 | P = .0001 | P = .056 | P = .26 | P = .045 | |
Gender (female vs. male) | 1.11 (0.83–1.47) | 1.07 (0.8–1.44) | 1.01 (0.75–1.37) | 1.48 (0.59–3.75) | 1.31 (0.49–3.53) | 1.68 (0.70–4.02) |
P = .47 | P = .64 | P = .94 | P = .41 | P = .29 | P = .24 | |
Multifocal vs. single lesion | 1.23 (0.80–1.88) | 1.26 (0.82–1.93) | 1.16 (0.74–1.81) | NA | NA | NA |
P = .34 | P = .29 | P = .52 | ||||
Tumor size (2-fold increase) | 1.00 (0.88–1.14) | 0.98 (0.87–1.11) | 1.03 (0.90–1.19) | 1.41 (0.87–2.29) | 1.56 (0.95–2.57) | 1.39 (0.89–2.16) |
P = .97 | P = .74 | P = .64 | P = .16 | P = .08 | P = .15 | |
Corticosteroid therapy (yes vs. no) | 2.13 (1.49–2.86) | 1.41 (1.02–1.92) | 2.17 (1.54–3.03) | 0.44 (0.17–1.11) | 0.78 (0.28–2.17) | 0.57 (0.23–1.39) |
P < .0001 | P = .036 | P < .0001 | P = .08 | P = .63 | P = .22 | |
ECOG performance status | ||||||
1 vs. 0 | 1.42 (1.04–1.94) | 1.33 (0.97–1.84) | 1.58 (1.13–2.20) | 0.26 (0.06–1.16) | 0.22 (0.05–0.97) | 0.22(0.05–0.97) |
2 vs. 0 | 2.31 (1.40–3.82) | 1.70 (1.03–2.80) | 2.34 (1.39–3.93) | 0.88 (0.18–4.19) | 0.71 (0.15–3.32) | 0.71(0.15–3.35) |
P = .0015 | P = .046 | P = .0007 | P = .21 | P = .13 | P = .13 |