Table 3 Costs associated with the management of adverse events
Unit cost | Pazopanib | Sunitinib | Cost difference | ||||
|---|---|---|---|---|---|---|---|
Adverse event | Value | Reference | Incidence | Per patient cost | Incidence | Per patient cost | |
Anorexia | [28] | €4.97 | €4.97 | €0.00 | |||
Grades I and II | €13.43 | 36% | 34% | ||||
Grade III | €13.43 | 1% | 3% | ||||
Diarrhea | [28] | €127.12 | €161.01 | -€33.89 | |||
Grades I and II | €6.05 | 54% | 49% | ||||
Grade III | €1,376.13 | 9% | 7% | ||||
Grade IV | €6,171.42 | 1% | |||||
Fatigue | [28] | €0.89 | €1.02 | -€0.13 | |||
Grades I and II | €1.62 | 44% | 45% | ||||
Grade III | €1.62 | 10% | 17% | ||||
Grade IV | €1.62 | 1% | 1% | ||||
Hand-foot syndrome | [29] | €23.30 | €52.20 | -€28.90 | |||
Grades I and II | €51.87 | 23% | 38% | ||||
Grade III | €189.41 | 6% | 11% | ||||
Grade IV | €1,165.50 | 1% | |||||
Hypertension | Expert judgment | €33.72 | €32.88 | €0.84 | |||
Grades I and II | €16.88 | 30% | 25% | ||||
Grade III | €16.88 | 15% | 15% | ||||
Grade IV | €2,612.71 | 1% | 1% | ||||
Nausea | [28] | €52.28 | €52.59 | -€0.31 | |||
Grades I and II | €31.24 | 43% | 44% | ||||
Grade III | €1,942.30 | 2% | 2% | ||||
Laboratory abnormality | |||||||
Anemia | [28] | €65.77 | €126.91 | -€61.14 | |||
Grades I and II | €200.26 | 29% | 53% | ||||
Grade III | €261.70 | 1% | 6% | ||||
Grade IV | €507.46 | 1% | 1% | ||||
ALT | Expert judgment | €136.70 | €79.77 | €56.93 | |||
Grades I and II | €119.30 | 43% | 38% | ||||
Grade III | €236.16 | 15% | 4% | ||||
Grade IV | €2,498.64 | 2% | 1% | ||||
Neutropenia | [28] | €138.00 | €248.60 | -€110.60 | |||
Grades I and II | €356.78 | 32% | 48% | ||||
Grade III | €356.78 | 4% | 19% | ||||
Grade IV | €955.53 | 1% | 1% | ||||
Trombocitopenia | [28] | €78.83 | €214.13 | -€135.30 | |||
Grades I and II | €139.29 | 37% | 56% | ||||
Grade III | €449.54 | 3% | 18% | ||||
Grade IV | €1,380.29 | 1% | 4% | ||||
Total | €661.58 | €974.08 | -€312.50 | ||||