Table 3 Univariate and multivariate survival analyses in pancreatic cancer
Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
Hazard ratio | 95% CI | p-value | Hazard ratio | 95% CI | p-value | |
IGF1R expression | ||||||
   Positive vs negative | 1.714 | 1.091-2.693 | 0.020 | |||
IGFBP3 low expression | ||||||
   Positive vs negative | 1.561 | 0.946-2.576 | 0.081 | |||
IGF1R (+) & IGFBP3 (−) | ||||||
   Positive vs negative | 3.101 | 1.843-5.218 | < 0.001 | 3.060 | 1.823-5.138 | < 0.001 |
Gender | ||||||
   male vs female | 0.975 | 0.623-1.525 | 0.911 | |||
Age | ||||||
   ≧ 60 vs <60 | 1.444 | 0.822-2.537 | 0.201 | |||
T category | ||||||
   3, 4 vs 1,2 | 1.844 | 0.997-3.413 | 0.051 | |||
Lymph node metastasis | ||||||
   Positive vs negative | 1.79 | 1.106-2.736 | 0.017 | 1.718 | 1.092-2.702 | 0.019 |
Tumor location | ||||||
   proximal vs distal | 1.108 | 0.671-1.736 | 0.752 | |||
Lymphatic invasion | ||||||
   Positive vs negative | 1.332 | 0.855-2.075 | 0.205 | |||
Arterial invasion | ||||||
   Positive vs negative | 1.209 | 0.554-2.637 | 0.634 | |||
Venous invasion | ||||||
   Positive vs negative | 1.579 | 0.812-3.071 | 0.178 | |||
Intrapancreatic nerve invasion | ||||||
   Positive vs negative | 1.452 | 0.930-2.267 | 0.101 | |||
Tumor differentiation | ||||||
   grade 1,2 vs grade 3,4 | 1.452 | 0.826-2.551 | 0.195 | |||
Tumor stromal volume | ||||||
   med/int vs scir | 0.724 | 0.453-1.156 | 0.176 | |||