Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells

BMC Cancer

Table 3 Somatic alteration in cohesion-related genes in cancer ^A

Gene	Percentage of somatic alterations^Bin
	Breast (482^C)			Colorectal (212^C)			Lung (178^C)			Ovarian (316^C)
	nsSNP	Del	Amp	nsSNP	Del	Amp	nsSNP	Del	Amp	nsSNP	Del	Amp
SMC1A	0.8	0.0	0.0	4.2	0.0	0.0	1.1	0.0	0.0	1.3	0.0	0.0
SMC3	0.2	0.2	0.0	1.4	0.9	0.0	2.8	0.6	0.0	0.3	0.0	0.0
RAD21	0.6	0.0	13.9	2.8	0.0	1.9	1.7	0.0	0.0	0.3	0.6	18.0
STAG2	1.2	0.0	0.0	2.8	0.0	0.0	3.4	0.0	0.0	0.9	0.0	0.0
PTTG1 ^B	0.0	0.4	0.2	0.5	0.0	0.0	1.1	0.6	0.0	0.0	0.0	0.9
ESPL1 ^C	1.5	0.0	0.2	3.3	0.0	0.0	4.5	0.0	0.6	0.0	0.3	0.6

^AOnly the Cancer Genome Atlas (TCGA) data is shown [21–24].
^Bnon-synonymous single nucleotide polymorphism (nsSNP), homozygous deletion (Del), gene amplification (Amp).
^CThe total number of tumors sequenced is indicated within parentheses.

ISSN: 1471-2407