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Table 3 Somatic alteration in cohesion-related genes in cancer A

From: Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells

Gene Percentage of somatic alterationsBin
Breast (482C) Colorectal (212C) Lung (178C) Ovarian (316C)
nsSNP Del Amp nsSNP Del Amp nsSNP Del Amp nsSNP Del Amp
SMC1A 0.8 0.0 0.0 4.2 0.0 0.0 1.1 0.0 0.0 1.3 0.0 0.0
SMC3 0.2 0.2 0.0 1.4 0.9 0.0 2.8 0.6 0.0 0.3 0.0 0.0
RAD21 0.6 0.0 13.9 2.8 0.0 1.9 1.7 0.0 0.0 0.3 0.6 18.0
STAG2 1.2 0.0 0.0 2.8 0.0 0.0 3.4 0.0 0.0 0.9 0.0 0.0
PTTG1 B 0.0 0.4 0.2 0.5 0.0 0.0 1.1 0.6 0.0 0.0 0.0 0.9
ESPL1 C 1.5 0.0 0.2 3.3 0.0 0.0 4.5 0.0 0.6 0.0 0.3 0.6
  1. AOnly the Cancer Genome Atlas (TCGA) data is shown [2124].
  2. Bnon-synonymous single nucleotide polymorphism (nsSNP), homozygous deletion (Del), gene amplification (Amp).
  3. CThe total number of tumors sequenced is indicated within parentheses.