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Table 4 Concordance between CNB and OEB for molecular subtypes

From: Preoperative core needle biopsy is accurate in determining molecular subtypes in invasive breast cancer

CNB

OEB

Concordance rate (%)

Kappa

(P value)

Using Ki67 = 14% as cutoff value for determining Luminal A and B in HR+/HER2- diseases

4 Subtypes

Luminal A

Luminal B

TNBC

HER2+

77.2

0.658 (<0.001)

  Luminal A

65

32

0

0

  

  Luminal B

15

106

7

7

  

  TNBC

0

1

37

1

  

  HER2+

0

4

1

22

  

5 Subtypes

Luminal A

Luminal B

TNBC

HER2+

75.8

0.679 (<0.001)

HER2-

HER2+

  Luminal A

65

31

1

0

0

  

  Luminal B

    HER2-

14

72

3

7

1

  

    HER2+

1

1

30

0

6

  

  TNBC

1

0

0

37

1

  

  HER2+

0

0

4

1

22

  

Using Ki67 = 20% as cutoff value for determining Luminal A and B in HR+/HER2- diseases

4 Subtypes

Luminal A

Luminal B

TNBC

HER2+

79.2

0.692 (<0.001)

  Luminal A

110

31

0

0

  

  Luminal B

10

67

7

7

  

  TNBC

1

0

37

1

  

  HER2+

0

4

1

22

  

5 Subtypes

Luminal A

Luminal B

TNBC

HER2+

78.2

0.699 (<0.001)

HER2-

HER2+

  Luminal A

110

29

2

0

0

  

  Luminal B

    HER2-

9

34

2

7

1

  

    HER2+

1

1

30

0

6

  

  TNBC

1

0

0

37

1

  

  HER2+

0

0

4

1

22

  
  1. Abbreviation: CNB, core needle biopsy; OEB, open excision biopsy; HR, hormonal receptor; TNBC, triple negative breast cancer.
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BMC Cancer

ISSN: 1471-2407

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