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Table 4 Concordance between CNB and OEB for molecular subtypes

From: Preoperative core needle biopsy is accurate in determining molecular subtypes in invasive breast cancer

CNB OEB Concordance rate (%) Kappa
(P value)
Using Ki67 = 14% as cutoff value for determining Luminal A and B in HR+/HER2- diseases
4 Subtypes Luminal A Luminal B TNBC HER2+ 77.2 0.658 (<0.001)
  Luminal A 65 32 0 0   
  Luminal B 15 106 7 7   
  TNBC 0 1 37 1   
  HER2+ 0 4 1 22   
5 Subtypes Luminal A Luminal B TNBC HER2+ 75.8 0.679 (<0.001)
HER2- HER2+
  Luminal A 65 31 1 0 0   
  Luminal B
    HER2- 14 72 3 7 1   
    HER2+ 1 1 30 0 6   
  TNBC 1 0 0 37 1   
  HER2+ 0 0 4 1 22   
Using Ki67 = 20% as cutoff value for determining Luminal A and B in HR+/HER2- diseases
4 Subtypes Luminal A Luminal B TNBC HER2+ 79.2 0.692 (<0.001)
  Luminal A 110 31 0 0   
  Luminal B 10 67 7 7   
  TNBC 1 0 37 1   
  HER2+ 0 4 1 22   
5 Subtypes Luminal A Luminal B TNBC HER2+ 78.2 0.699 (<0.001)
HER2- HER2+
  Luminal A 110 29 2 0 0   
  Luminal B
    HER2- 9 34 2 7 1   
    HER2+ 1 1 30 0 6   
  TNBC 1 0 0 37 1   
  HER2+ 0 0 4 1 22   
  1. Abbreviation: CNB, core needle biopsy; OEB, open excision biopsy; HR, hormonal receptor; TNBC, triple negative breast cancer.