Plasma S-adenosylmethionine, DNMTpolymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore

Inoue-Choi, Maki; Nelson, Heather H; Robien, Kim; Arning, Erland; Bottiglieri, Teodoro; Koh, Woon-Puay; Yuan, Jian-Min

doi:10.1186/1471-2407-13-389

Table 4 LINE-1 methylation index (%) by genotypes of DNMT1 , DNMT3A and DNMT3B in the Singapore Chinese health study

From: Plasma S-adenosylmethionine, DNMTpolymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore

	Men				Women
	n^a	Mean (95% CI)^b	p	p _trend	n^a	Mean (95% CI)^b	p	p _trend
*DNMT1*
rs2114724
CC	90	77.7 (77.2 – 78.1)		0.001	126	77.2 (76.8 – 77.6)		0.38
CT	71	78.3 (77.8 – 78.8)	0.06		98	77.6 (77.1 – 78.1)	0.25
TT	21	79.3 (78.4 – 80.3)	0.002		20	77.4 (76.3 – 78.5)	0.75
rs2241531
GG	44	77.9 (77.2 – 78.5)		0.11	61	77.1 (76.5 – 77.7)		0.71
CG	94	78.1 (77.6 – 78.5)	0.60		121	77.5 (77.1 – 78.0)	0.29
CC	46	78.6 (78.0 – 79.2)	0.11		63	77.3 (76.7 – 77.9)	0.70
rs2288350
CC	55	78.5 (77.9 – 79.1)		0.05	74	77.4 (76.8 – 78.0)		0.57
CT	93	78.1 (77.6 – 78.6)	0.31		115	77.5 (77.0 – 77.9)	0.85
TT	38	77.6 (76.9 – 78.3)	0.05		55	77.1 (76.5 – 77.8)	0.53
rs7253062
GG	109	78.3 (77.9 – 78.7)		0.12	149	77.3 (76.9 – 77.7)		0.92
GA	72	77.8 (77.3 – 78.3)	0.13		83	77.5 (76.9 – 78.0)	0.71
AA	4	77.6 (75.4 – 79.8)	0.54		11	77.1 (75.7 – 78.6)	0.78
*DNMT3A*
rs1550117
CC	113	78.3 (77.8 – 78.7)		0.10	146	77.5 (77.1 – 77.9)		0.30
CT	58	78.0 (77.4 – 78.5)	0.39		92	77.1 (76.6 – 77.6)	0.24
TT	15	77.3 (76.2 – 78.4)	0.12		8	77.3 (75.6 – 79.0)	0.83
rs6722613
GG	93	78.0 (77.6 – 78.5)		0.87	101	77.4 (76.9 – 77.9)		0.69
GA	69	78.2 (77.7 – 78.8)	0.58		112	77.4 (76.9 – 77.8)	0.93
AA	24	78.0 (77.1 – 78.9)	0.93		33	77.2 (76.3 – 78.0)	0.65
rs7575625
AA	115	78.2 (77.8 – 78.6)		0.29	148	77.3 (76.9 – 77.7)		0.79
AG	59	78.2 (77.7 – 78.8)	0.86		83	77.3 (76.8 – 77.8)	0.98
GG	11	77.0 (75.7 – 78.2)	0.08		15	77.6 (76.4 – 78.9)	0.66
rs7581217
CC	59	78.5 (78.0 – 79.1)		0.008	83	77.5 (77.0 – 78.0)		0.92
CT	94	78.1 (77.7 – 78.6)	0.27		114	77.1 (76.7 – 77.6)	0.26
TT	33	77.2 (76.4 – 77.8)	0.006		49	77.6 (76.9 – 78.3)	0.90
rs7587636
GG	95	78.1 (77.6 – 78.5)		0.89	116	77.2 (76.8 – 77.7)		0.95
GA	68	78.2 (77.6 – 78.7)	0.86		103	77.6 (77.1 – 78.0)	0.32
AA	22	78.1 (77.2 – 79.1)	0.94		27	77.0 (76.0 – 77.9)	0.57
rs13036246
CC	102	78.0 (77.5 – 78.4)		0.26	129	77.5 (77.1 – 77.9)		0.14
CT	68	78.2 (77.7 – 78.7)	0.47		106	77.3 (76.8 – 77.7)	0.48
TT	15	78.6 (77.5 – 79.7)	0.31		10	76.1 (74.6 – 77.6)	0.08
rs34048824
TT	116	78.1 (77.7 – 78.5)		0.61	150	77.3 (76.9 – 77.7)		0.70
TC	58	78.3 (77.8 – 78.9)	0.59		77	77.3 (76.8 – 77.9)	0.99
CC	10	77.1 (75.8 – 78.5)	0.18		18	77.7 (76.5 – 78.8)	0.57
*DNMT3B*
rs2424908
CC	61	77.9 (77.3 – 78.4)		0.83	88	77.4 (76.9 – 77.9)		0.88
CT	79	78.4 (77.9 – 78.9)	0.18		121	77.3 (76.9 – 77.8)	0.88
TT	44	77.9 (77.2 – 78.6)	0.96		37	77.3 (76.5 – 78.1)	0.91
rs6141813
AA	82	78.0 (77.5 – 78.5)		0.76	103	77.2 (76.8 – 77.7)		0.74
AG	73	78.3 (77.8 – 78.8)	0.35		115	77.4 (77.0 – 77.9)	0.56
GG	30	78.0 (77.2 – 78.8)	0.99		27	77.3 (76.3 – 78.2)	0.94

^aSubjects with missing data on a genotype of each SNP were excluded from an analysis.
^bAdjusted for age at blood draw.

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ISSN: 1471-2407

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