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Table 4 LINE-1 methylation index (%) by genotypes of DNMT1 , DNMT3A and DNMT3B in the Singapore Chinese health study

From: Plasma S-adenosylmethionine, DNMTpolymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore

  Men Women
  na Mean (95% CI)b p p trend na Mean (95% CI)b p p trend
DNMT1         
rs2114724         
  CC 90 77.7 (77.2 – 78.1)   0.001 126 77.2 (76.8 – 77.6)   0.38
  CT 71 78.3 (77.8 – 78.8) 0.06   98 77.6 (77.1 – 78.1) 0.25  
  TT 21 79.3 (78.4 – 80.3) 0.002   20 77.4 (76.3 – 78.5) 0.75  
rs2241531         
  GG 44 77.9 (77.2 – 78.5)   0.11 61 77.1 (76.5 – 77.7)   0.71
  CG 94 78.1 (77.6 – 78.5) 0.60   121 77.5 (77.1 – 78.0) 0.29  
  CC 46 78.6 (78.0 – 79.2) 0.11   63 77.3 (76.7 – 77.9) 0.70  
rs2288350         
  CC 55 78.5 (77.9 – 79.1)   0.05 74 77.4 (76.8 – 78.0)   0.57
  CT 93 78.1 (77.6 – 78.6) 0.31   115 77.5 (77.0 – 77.9) 0.85  
  TT 38 77.6 (76.9 – 78.3) 0.05   55 77.1 (76.5 – 77.8) 0.53  
rs7253062         
  GG 109 78.3 (77.9 – 78.7)   0.12 149 77.3 (76.9 – 77.7)   0.92
  GA 72 77.8 (77.3 – 78.3) 0.13   83 77.5 (76.9 – 78.0) 0.71  
  AA 4 77.6 (75.4 – 79.8) 0.54   11 77.1 (75.7 – 78.6) 0.78  
DNMT3A         
rs1550117         
  CC 113 78.3 (77.8 – 78.7)   0.10 146 77.5 (77.1 – 77.9)   0.30
  CT 58 78.0 (77.4 – 78.5) 0.39   92 77.1 (76.6 – 77.6) 0.24  
  TT 15 77.3 (76.2 – 78.4) 0.12   8 77.3 (75.6 – 79.0) 0.83  
rs6722613         
  GG 93 78.0 (77.6 – 78.5)   0.87 101 77.4 (76.9 – 77.9)   0.69
  GA 69 78.2 (77.7 – 78.8) 0.58   112 77.4 (76.9 – 77.8) 0.93  
  AA 24 78.0 (77.1 – 78.9) 0.93   33 77.2 (76.3 – 78.0) 0.65  
rs7575625         
  AA 115 78.2 (77.8 – 78.6)   0.29 148 77.3 (76.9 – 77.7)   0.79
  AG 59 78.2 (77.7 – 78.8) 0.86   83 77.3 (76.8 – 77.8) 0.98  
  GG 11 77.0 (75.7 – 78.2) 0.08   15 77.6 (76.4 – 78.9) 0.66  
rs7581217         
  CC 59 78.5 (78.0 – 79.1)   0.008 83 77.5 (77.0 – 78.0)   0.92
  CT 94 78.1 (77.7 – 78.6) 0.27   114 77.1 (76.7 – 77.6) 0.26  
  TT 33 77.2 (76.4 – 77.8) 0.006   49 77.6 (76.9 – 78.3) 0.90  
rs7587636   
  GG 95 78.1 (77.6 – 78.5)   0.89 116 77.2 (76.8 – 77.7)   0.95
  GA 68 78.2 (77.6 – 78.7) 0.86   103 77.6 (77.1 – 78.0) 0.32  
  AA 22 78.1 (77.2 – 79.1) 0.94   27 77.0 (76.0 – 77.9) 0.57  
rs13036246         
  CC 102 78.0 (77.5 – 78.4)   0.26 129 77.5 (77.1 – 77.9)   0.14
  CT 68 78.2 (77.7 – 78.7) 0.47   106 77.3 (76.8 – 77.7) 0.48  
  TT 15 78.6 (77.5 – 79.7) 0.31   10 76.1 (74.6 – 77.6) 0.08  
rs34048824         
  TT 116 78.1 (77.7 – 78.5)   0.61 150 77.3 (76.9 – 77.7)   0.70
  TC 58 78.3 (77.8 – 78.9) 0.59   77 77.3 (76.8 – 77.9) 0.99  
  CC 10 77.1 (75.8 – 78.5) 0.18   18 77.7 (76.5 – 78.8) 0.57  
DNMT3B         
rs2424908         
  CC 61 77.9 (77.3 – 78.4)   0.83 88 77.4 (76.9 – 77.9)   0.88
  CT 79 78.4 (77.9 – 78.9) 0.18   121 77.3 (76.9 – 77.8) 0.88  
  TT 44 77.9 (77.2 – 78.6) 0.96   37 77.3 (76.5 – 78.1) 0.91  
rs6141813         
  AA 82 78.0 (77.5 – 78.5)   0.76 103 77.2 (76.8 – 77.7)   0.74
  AG 73 78.3 (77.8 – 78.8) 0.35   115 77.4 (77.0 – 77.9) 0.56  
  GG 30 78.0 (77.2 – 78.8) 0.99   27 77.3 (76.3 – 78.2) 0.94  
  1. aSubjects with missing data on a genotype of each SNP were excluded from an analysis.
  2. bAdjusted for age at blood draw.