|
Men
|
Women
|
---|
|
na
|
Mean (95% CI)b
|
p
|
p
trend
|
na
|
Mean (95% CI)b
|
p
|
p
trend
|
---|
DNMT1
| | | | | | | | |
rs2114724
| | | | | | | | |
CC
|
90
|
77.7 (77.2 – 78.1)
| |
0.001
|
126
|
77.2 (76.8 – 77.6)
| |
0.38
|
CT
|
71
|
78.3 (77.8 – 78.8)
|
0.06
| |
98
|
77.6 (77.1 – 78.1)
|
0.25
| |
TT
|
21
|
79.3 (78.4 – 80.3)
|
0.002
| |
20
|
77.4 (76.3 – 78.5)
|
0.75
| |
rs2241531
| | | | | | | | |
GG
|
44
|
77.9 (77.2 – 78.5)
| |
0.11
|
61
|
77.1 (76.5 – 77.7)
| |
0.71
|
CG
|
94
|
78.1 (77.6 – 78.5)
|
0.60
| |
121
|
77.5 (77.1 – 78.0)
|
0.29
| |
CC
|
46
|
78.6 (78.0 – 79.2)
|
0.11
| |
63
|
77.3 (76.7 – 77.9)
|
0.70
| |
rs2288350
| | | | | | | | |
CC
|
55
|
78.5 (77.9 – 79.1)
| |
0.05
|
74
|
77.4 (76.8 – 78.0)
| |
0.57
|
CT
|
93
|
78.1 (77.6 – 78.6)
|
0.31
| |
115
|
77.5 (77.0 – 77.9)
|
0.85
| |
TT
|
38
|
77.6 (76.9 – 78.3)
|
0.05
| |
55
|
77.1 (76.5 – 77.8)
|
0.53
| |
rs7253062
| | | | | | | | |
GG
|
109
|
78.3 (77.9 – 78.7)
| |
0.12
|
149
|
77.3 (76.9 – 77.7)
| |
0.92
|
GA
|
72
|
77.8 (77.3 – 78.3)
|
0.13
| |
83
|
77.5 (76.9 – 78.0)
|
0.71
| |
AA
|
4
|
77.6 (75.4 – 79.8)
|
0.54
| |
11
|
77.1 (75.7 – 78.6)
|
0.78
| |
DNMT3A
| | | | | | | | |
rs1550117
| | | | | | | | |
CC
|
113
|
78.3 (77.8 – 78.7)
| |
0.10
|
146
|
77.5 (77.1 – 77.9)
| |
0.30
|
CT
|
58
|
78.0 (77.4 – 78.5)
|
0.39
| |
92
|
77.1 (76.6 – 77.6)
|
0.24
| |
TT
|
15
|
77.3 (76.2 – 78.4)
|
0.12
| |
8
|
77.3 (75.6 – 79.0)
|
0.83
| |
rs6722613
| | | | | | | | |
GG
|
93
|
78.0 (77.6 – 78.5)
| |
0.87
|
101
|
77.4 (76.9 – 77.9)
| |
0.69
|
GA
|
69
|
78.2 (77.7 – 78.8)
|
0.58
| |
112
|
77.4 (76.9 – 77.8)
|
0.93
| |
AA
|
24
|
78.0 (77.1 – 78.9)
|
0.93
| |
33
|
77.2 (76.3 – 78.0)
|
0.65
| |
rs7575625
| | | | | | | | |
AA
|
115
|
78.2 (77.8 – 78.6)
| |
0.29
|
148
|
77.3 (76.9 – 77.7)
| |
0.79
|
AG
|
59
|
78.2 (77.7 – 78.8)
|
0.86
| |
83
|
77.3 (76.8 – 77.8)
|
0.98
| |
GG
|
11
|
77.0 (75.7 – 78.2)
|
0.08
| |
15
|
77.6 (76.4 – 78.9)
|
0.66
| |
rs7581217
| | | | | | | | |
CC
|
59
|
78.5 (78.0 – 79.1)
| |
0.008
|
83
|
77.5 (77.0 – 78.0)
| |
0.92
|
CT
|
94
|
78.1 (77.7 – 78.6)
|
0.27
| |
114
|
77.1 (76.7 – 77.6)
|
0.26
| |
TT
|
33
|
77.2 (76.4 – 77.8)
|
0.006
| |
49
|
77.6 (76.9 – 78.3)
|
0.90
| |
rs7587636
| | |
GG
|
95
|
78.1 (77.6 – 78.5)
| |
0.89
|
116
|
77.2 (76.8 – 77.7)
| |
0.95
|
GA
|
68
|
78.2 (77.6 – 78.7)
|
0.86
| |
103
|
77.6 (77.1 – 78.0)
|
0.32
| |
AA
|
22
|
78.1 (77.2 – 79.1)
|
0.94
| |
27
|
77.0 (76.0 – 77.9)
|
0.57
| |
rs13036246
| | | | | | | | |
CC
|
102
|
78.0 (77.5 – 78.4)
| |
0.26
|
129
|
77.5 (77.1 – 77.9)
| |
0.14
|
CT
|
68
|
78.2 (77.7 – 78.7)
|
0.47
| |
106
|
77.3 (76.8 – 77.7)
|
0.48
| |
TT
|
15
|
78.6 (77.5 – 79.7)
|
0.31
| |
10
|
76.1 (74.6 – 77.6)
|
0.08
| |
rs34048824
| | | | | | | | |
TT
|
116
|
78.1 (77.7 – 78.5)
| |
0.61
|
150
|
77.3 (76.9 – 77.7)
| |
0.70
|
TC
|
58
|
78.3 (77.8 – 78.9)
|
0.59
| |
77
|
77.3 (76.8 – 77.9)
|
0.99
| |
CC
|
10
|
77.1 (75.8 – 78.5)
|
0.18
| |
18
|
77.7 (76.5 – 78.8)
|
0.57
| |
DNMT3B
| | | | | | | | |
rs2424908
| | | | | | | | |
CC
|
61
|
77.9 (77.3 – 78.4)
| |
0.83
|
88
|
77.4 (76.9 – 77.9)
| |
0.88
|
CT
|
79
|
78.4 (77.9 – 78.9)
|
0.18
| |
121
|
77.3 (76.9 – 77.8)
|
0.88
| |
TT
|
44
|
77.9 (77.2 – 78.6)
|
0.96
| |
37
|
77.3 (76.5 – 78.1)
|
0.91
| |
rs6141813
| | | | | | | | |
AA
|
82
|
78.0 (77.5 – 78.5)
| |
0.76
|
103
|
77.2 (76.8 – 77.7)
| |
0.74
|
AG
|
73
|
78.3 (77.8 – 78.8)
|
0.35
| |
115
|
77.4 (77.0 – 77.9)
|
0.56
| |
GG
|
30
|
78.0 (77.2 – 78.8)
|
0.99
| |
27
|
77.3 (76.3 – 78.2)
|
0.94
| |
-
aSubjects with missing data on a genotype of each SNP were excluded from an analysis.
-
bAdjusted for age at blood draw.