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Table 3 LINE-1 methylation index (%) by plasma SAM level in the Singapore Chinese health study

From: Plasma S-adenosylmethionine, DNMTpolymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore

Men Women
SAM (nmol/L) n LINE-1 methylationa p SAM (nmol/L) n LINE-1 methylationa p trend
< 55 38 77.3 (76.6 – 78.0) 0.01 < 50 48 76.6 (75.9 – 77.2) 0.005
≥ 55 154 78.3 (77.9 – 78.6)   50 – < 90 180 77.5 (77.1 – 77.8)b  
     ≥ 90 20 78.3 (77.2 – 79.4)c  
  1. aMean (95% CI) adjusted for age at blood draw and serum creatinine level.
  2. b p = 0.02 compared to plasma SAM levels <50 nmol/L.
  3. c p = 0.01 compared to plasma SAM levels <50 nmol/L.