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Table 3 LINE-1 methylation index (%) by plasma SAM level in the Singapore Chinese health study

From: Plasma S-adenosylmethionine, DNMTpolymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore

Men

Women

SAM (nmol/L)

n

LINE-1 methylationa

p

SAM (nmol/L)

n

LINE-1 methylationa

p trend

< 55

38

77.3 (76.6 – 78.0)

0.01

< 50

48

76.6 (75.9 – 77.2)

0.005

≥ 55

154

78.3 (77.9 – 78.6)

 

50 – < 90

180

77.5 (77.1 – 77.8)b

 
    

≥ 90

20

78.3 (77.2 – 79.4)c

 
  1. aMean (95% CI) adjusted for age at blood draw and serum creatinine level.
  2. b p = 0.02 compared to plasma SAM levels <50 nmol/L.
  3. c p = 0.01 compared to plasma SAM levels <50 nmol/L.
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BMC Cancer

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