BMC Cancer

Table 2 LINE-1 methylation index (%) by demographic and lifestyle factors in the Singapore Chinese health study

From: Plasma S-adenosylmethionine, DNMTpolymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore

	Men			Women
	n	Mean (95% CI)^a	p _trend	n	Mean (95% CI)^a	p _trend
LINE-1 methylation (%)	192	78.1 (77.8 – 78.4)^b	-	248	77.3 (77.1 – 77.6)^b	-
Age
<50	25	77.8 (77.0 – 78.7)	0.04	41	77.0 (76.3 – 77.8)	0.82
50 – 59	79	77.8 (77.3 – 78.3)		123	77.6 (77.1 – 78.0)
60 – 69	71	78.2 (77.7 – 78.7)		55	77.2 (76.5 – 77.8)
≥70	17	79.3 (78.2 – 80.3)		29	77.1 (76.3 – 78.0)
BMI
<20	23	78.3 (77.4 – 79.2)	0.31	38	77.3 (76.5 – 78.1)	0.08
20 – <24	112	77.8 (77.4 – 78.3)		143	77.6 (77.2 – 78.0)
24 – <28	49	78.4 (77.7 – 79.0)		56	76.9 (76.3 – 77.5)
≥28	8	78.9 (77.4 – 80.4)		11	76.1 (74.7 – 77.6)
Level of education
No formal school	27	77.8 (76.9 – 78.6)	0.28	93	77.0 (76.5 – 77.6)	0.19
Primary school	89	77.9 (77.5 – 78.4)		94	77.5 (77.0 – 78.0)
Secondary school	53	78.5 (77.9 – 79.1)		52	77.6 (76.9 – 78.3)
Some college or above	23	78.2 (77.2 – 79.1)		9	77.6 (76.0 – 79.2)
Smoking status
Never	84	78.2 (77.7 – 78.7)	0.60	234	77.4 (77.1 – 77.7)	0.21
Past	49	78.0 (77.4 – 78.7)		2	78.5 (75.1 – 81.9)
Current	59	78.0 (77.4 – 78.6)		12	76.4 (74.9 – 77.8)
Alcohol intake
None	135	78.1 (77.7 – 78.5)	0.98	231	77.4 (77.1 – 77.7)	0.12
<7 drinks/week	42	78.1 (77.4 – 78.8)		13	77.1 (75.7 – 78.4)
≥7 drinks/week	15	78.0 (76.9 – 79.2)		4	75.3 (72.9 – 77.7)

^aAdjusted for age at blood draw.
^b p for difference between men and women was 0.001.

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