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Table 2 LINE-1 methylation index (%) by demographic and lifestyle factors in the Singapore Chinese health study

From: Plasma S-adenosylmethionine, DNMTpolymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore

  Men Women
  n Mean (95% CI)a p trend n Mean (95% CI)a p trend
LINE-1 methylation (%) 192 78.1 (77.8 – 78.4)b - 248 77.3 (77.1 – 77.6)b -
Age       
  <50 25 77.8 (77.0 – 78.7) 0.04 41 77.0 (76.3 – 77.8) 0.82
  50 – 59 79 77.8 (77.3 – 78.3)   123 77.6 (77.1 – 78.0)  
  60 – 69 71 78.2 (77.7 – 78.7)   55 77.2 (76.5 – 77.8)  
  ≥70 17 79.3 (78.2 – 80.3)   29 77.1 (76.3 – 78.0)  
BMI       
  <20 23 78.3 (77.4 – 79.2) 0.31 38 77.3 (76.5 – 78.1) 0.08
  20 – <24 112 77.8 (77.4 – 78.3)   143 77.6 (77.2 – 78.0)  
  24 – <28 49 78.4 (77.7 – 79.0)   56 76.9 (76.3 – 77.5)  
  ≥28 8 78.9 (77.4 – 80.4)   11 76.1 (74.7 – 77.6)  
Level of education       
  No formal school 27 77.8 (76.9 – 78.6) 0.28 93 77.0 (76.5 – 77.6) 0.19
  Primary school 89 77.9 (77.5 – 78.4)   94 77.5 (77.0 – 78.0)  
  Secondary school 53 78.5 (77.9 – 79.1)   52 77.6 (76.9 – 78.3)  
  Some college or above 23 78.2 (77.2 – 79.1)   9 77.6 (76.0 – 79.2)  
Smoking status       
  Never 84 78.2 (77.7 – 78.7) 0.60 234 77.4 (77.1 – 77.7) 0.21
  Past 49 78.0 (77.4 – 78.7)   2 78.5 (75.1 – 81.9)  
  Current 59 78.0 (77.4 – 78.6)   12 76.4 (74.9 – 77.8)  
Alcohol intake       
  None 135 78.1 (77.7 – 78.5) 0.98 231 77.4 (77.1 – 77.7) 0.12
  <7 drinks/week 42 78.1 (77.4 – 78.8)   13 77.1 (75.7 – 78.4)  
  ≥7 drinks/week 15 78.0 (76.9 – 79.2)   4 75.3 (72.9 – 77.7)  
  1. aAdjusted for age at blood draw.
  2. b p for difference between men and women was 0.001.