Intervention | Dose | Study | N | STS subtypes (%) |
---|---|---|---|---|
Brostallicin | 10 mg/m2 | Leahy 2007 [33] | 43 | Multiple |
Cisplatin | 50 mg/m2 | Thigpen 1986 [34] | 20 | Leiomyosarcoma |
Cyclophosphamide | 1.5 g/m2 | 18 | NS | |
Dacarbazine | 1200 mg/m2 | Buesa 1991 [73] | 47 | Multiple |
Docetaxel | 100 mg/m2 | Kostler 2001 [37] | 25 | Multiple |
Docetaxel | 100 mg/m2 | Santoro 1999 [38] | 37 | Multiple |
Docetaxel | 100 mg/m2 | 21 | NS | |
Doxorubicin | 75 mg/m2 | Mouridsen 1987 [41] | 23 | NS |
Etoposide | 200-240 mg/m2/day | Crawley 1997 [42] | 17 | Multiple |
Etoposide | 130 mg/m2 | Dombernowsky 1987 [43] | 26 | NS |
Gefitinib | 500 mg | Ray-Coquard 2008 [44] | 48 | Synovial sarcoma≈ |
Gemcitabine | 1000 mg/m2 | Ferraresi 2008 [74] | 14 | Multiple |
Gemcitabine | 1000 mg/m2 | Hartmann 2006 [45] | 15 | Multiple |
Gemcitabine | 1000 mg/m2 | Look 2004 [75] | 35 | Leiomyosarcoma |
Gemcitabine | 200-250 mg/m2 | Spath-Schwalbe 2000 [46] | 18 | Multiple |
Ifosfamide | 2 g/m2 for 4d q3w | Antman 1985 [47] | 31 | Multiple |
Ifosfamide | 2 g/m2 for 4d q3w | Antman 1989 [48] | 94 | Multiple |
Ifosfamide | 1 g/m2 daily until Gr3 granulocytopenia q4w | Babovic 1998 [76] | 21 | Multiple |
Ifosfamide | 4 g/m2 for 3d q4w | 40 | Multiple | |
Ifosfamide | 4 g/m2 for 3d q4w | Nielsen 2000 [78] | 13 | NS |
Ifosfamide | 3.5 g/m2 for 4d q3w | Palumbo 1997 [79] | 38 | Multiple |
Ifosfamide | 4 g/m2 for 3.5d q3w | Patel 1997 [80] | 12 | Multiple |
Ifosfamide | 2g/m2 loading dose followed by 4g/m2 for 3d q3w | Patel 1997 [80] | 32 | Multiple |
Ifosfamide | 60 mg/kg for 5d q3-4w | Scheulen 1983 [81] | 16 | NS |
Liposomal doxorubicin | 55 mg/m2 | Skubitz 2003 [50] | 20 | Multiple |
Liposomal doxorubicin | 30-50 mg/m2 | Toma 2000 [51] | 25 | Multiple |
Methotrexate | 40 mg/m2 | Buesa 1984 [52] | 37 | NS |
Paclitaxel | 135-175 mg/m2 | Palumbo 1997 [53] | 12 | Multiple |
Paclitaxel | 200 mg/m2 | Patel 1997 [54] | 12 | Multiple |
Paclitaxel | 120 mg/m2 | Skubitz 1997 [55] | 17 | Multiple |
Sorafenib | 400 mg | 61 | Multiple | |
Sorafenib | 400 mg | Pacey 2011 [28] | 16 | Multiple |
Sunitinib | 50 mg | Decoster 2010 [58] | 24 | NS |
Trabectedin | 1.5 mg/m2 | 36 | Multiple | |
Trabectedin | 1.5 mg/m2 | Le Cesne 2005 [83] | 104 | Multiple |
Trabectedin | 1.5 mg/m2 | 27 | Multiple | |
Biricodar + doxorubicin | B - 120 mg1.5 mg/m2/hr; D – 60 mg/m2 | Bramwell 2002 [62] | 18 | Multiple |
Cisplatin + ifosfamide | C – 100 mg/m2 day 2&9; I −2.5 g/m2 for 3d | Budd 1993 [85] | 38 | Multiple |
Cisplatin + vinblastine | C – 50–100 mg/m2 day 1; V – 1.0-1.2 mg/m2 for 5d | Keohan 1997 [63] | 18 | Multiple |
D + IL-2 | D – 70 mg/m2; IL-2 - 18 MIU/m2 | Le Cesne 1999 [64] | 12 | NS |
Epirubicin + lonidamine | E – 120 mg/m2; I – 150–450 mg | Lopez 1995 [65] | 25 | Multiple |
Etoposide + ifosfamide | E – 200 mg/m2 for 3d; I – 1.5 g/m2 for 3d | Saeter 1995 [86] | 11 | NS |
Etoposide + ifosfamide | E – 50 mg/m2 for 8d; I - 1.5 g/m2 for 6d | Skubitz 1993 [87] | 16 | Multiple |
Gemcitabine + dacarbazine | G – 800–2160 mg/m2; DTIC – 500 mg/m2 | Buesa 2004 [66] | 22 | Multiple |
Gemcitabine + dacarbazine | G – 1800 mg/m2; DTIC – 500 mg/m2 | Losa 2007 [67] | 26 | Multiple |
Gemcitabine + docetaxel | G – 900 mg/m2; D – 100 mg/m2 | Hensley 2002 [88] | 16 | Leiomyosarcoma |
Gemcitabine + docetaxel | G – 900 mg/m2; D – 100 mg/m2 | Hensley 2008 [89] | 51 | Leiomyosarcoma |
Gemcitabine + docetaxel | G – 900 mg/m2; D – 100 mg/m2 | Montalar 2008 [68] | 12 | Multiple |
Methotrexate + vincristine | M – 5 g/m2; V – 1 mg/m2 | Vaughn 1984 [69] | 14 | NS |
VAC + IE | V – 2 mg; A – 70 mg/m2; C – 600 mg/m2; I – 1.8 g/m2; E – 500 mg/m2 | Palumbo 1998 [70] | 12 | NS |
C + VC + D + DTIC + IL-2 | IL-2 – 18 m units/d, followed by CYVADIC | Gravis 2001 [71] | 1 | Leiomyosarcoma |
D + I + DTIC + IL-2 | IL-2 – 18 m units/d, followed by D+I+DTIC | Gravis 2001 [71] | 9 | Multiple |
D + IL-2 | IL-2 – 18 m units/d, followed by D | Gravis 2001 [71] | 3 | Multiple |
Carboplatin + etoposide | C – 300 mg/m2; E – 300 mg/m2 | Holstein 1996 [72] | 8 | Multiple |
Dacarbazine | 1200 mg/m2 | Holstein 1996 [72] | 14 | Multiple |