Knockdown of Nrf2 attenuates the tumorigenicity of GSCs in vivo. (A) The differences in tumor volume upon harvest of xenograft tumor from the Scrambled or the Nrf2 shRNA lentivirus treated groups in node mices. (B) morphology of tumors in the node mices. (C) curve of tumor volume in node mices. procreating GSCs treated with Nrf2 shRNA lentivirus resulted in tumor volume of 210 ± 57 mm3, compared with a much larger volume of 1850 ± 260 mm3 in scrambled tumors and 1900 ± 300 mm3 in control tumors.