Skip to main content

Table 3 Concentration of cytokines in tumors 5 days after the combined modality treatment

From: Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma

Therapeutic group

mIL-12

mIFNγ

Control groups

< 330 pg/g

< 2820 pg/g

EGT mIL-12

1027 ± 400 pg/g *

6509 ± 1018 pg/g *

EGT mIL-12 + IR

1671 ± 529 pg/g *

7191 ± 1283 pg/g *

  1. Therapeutic groups: mIL-12 gene electrotransfer alone (EGT mIL-12) or combined with tumor irradiation (EGT mIL-12 + IR). Control groups are untreated control, 10 Gy single dose irradiation (IR), electrical pulse application alone (EP) or combined with irradiation (EP + IR), intratumoral injection of plasmid DNA coding for mIL-12 or dsRed alone (mIL-12, dsRed) or combined with irradiation (mIL-12 + IR, dsRed + IR), dsRed gene electrotransfer alone (EGT dsRed) or combined with irradiation (EGT dsRed + IR).
  2. Abbreviations:
  3. mIL-12 – intratumoral levels of mIL-12.
  4. mIFNγ – intratumoral levels of mIFNγ.
  5. * Statistically significant difference compared to untreated control (p < 0.05).
  6. Number of animals in control groups was 8 – 9. Number of animals in groups EGT mIL-12 and EGT mIL-12 + IR was pooled from two experiments and was 17–18.