Therapeutic group | mIL-12 | mIFNγ |
---|
Control groups | < 330 pg/g | < 2820 pg/g |
EGT mIL-12 | 1027 ± 400 pg/g * | 6509 ± 1018 pg/g * |
EGT mIL-12 + IR | 1671 ± 529 pg/g * | 7191 ± 1283 pg/g * |
- Therapeutic groups: mIL-12 gene electrotransfer alone (EGT mIL-12) or combined with tumor irradiation (EGT mIL-12 + IR). Control groups are untreated control, 10 Gy single dose irradiation (IR), electrical pulse application alone (EP) or combined with irradiation (EP + IR), intratumoral injection of plasmid DNA coding for mIL-12 or dsRed alone (mIL-12, dsRed) or combined with irradiation (mIL-12 + IR, dsRed + IR), dsRed gene electrotransfer alone (EGT dsRed) or combined with irradiation (EGT dsRed + IR).
- Abbreviations:
- mIL-12 – intratumoral levels of mIL-12.
- mIFNγ – intratumoral levels of mIFNγ.
- * Statistically significant difference compared to untreated control (p < 0.05).
- Number of animals in control groups was 8 – 9. Number of animals in groups EGT mIL-12 and EGT mIL-12 + IR was pooled from two experiments and was 17–18.