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Table 1 Antitumor effectiveness of single mIL-12 gene electrotransfer alone or combined with irradiation on SA-1 sarcoma

From: Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma

Therapeutic group N DT (days; AM ± SE)* GD (days; AM ± SE)** Cures†(%; n) SC resistance#
Control 12 1.7 ± 0.2 - 0  
EP 13 4.2 ± 0.6 2.5 ± 0.6 0  
dsRed 12 3.1 ± 0.3 1.3 ± 0.3 0  
EGT dsRed 14 5.3 ± 0.9 3.5 ± 0.9 0  
mIL-12 13 3.1 ± 0.4 1.4 ± 0.4 0  
EGT mIL12 14 20.0 ± 3.0 ‡ 18.3 ± 3.0 7.1 (1/14) 0/1
IR 13 5.4 ± 0.9 3.7 ± 0.9 0  
EP + IR 14 14.4 ± 4.2 ‡ 12.7 ± 4.2 0  
dsRed + IR 9 5.3 ± 1.1 3.6 ± 1.1 0  
EGT dsRed + IR 11 9.3 ± 1.9 7.5 ± 1.9 0  
mIL-12 + IR 13 10.7 ± 1.7 8.9 ± 1.7 0  
EGT mIL-12 + IR 14 32.6 ± 4.3 ‡§ 30.9 ± 4.3 § 21.4 (3/14) 1/3
  1. Therapeutic groups: 10 Gy single dose irradiation (IR), electrical pulse application alone (EP) or combined with irradiation (EP + IR), intratumoral injection of plasmid DNA coding for mIL-12 or dsRed alone (mIL-12, dsRed) or combined with irradiation (mIL-12 + IR, dsRed + IR), mIL-12 or dsRed gene electrotransfer alone (EGT mIL-12, EGT dsRed) or combined with irradiation (EGT mIL-12 + IR, EGT dsRed + IR).
  2. N - Number of all mice in the group.
  3. * - Tumor doubling time - only mice with tumors were included in calculation.
  4. ** - Tumor growth delay - only mice with tumors were included in calculation.
  5. † - Cures were determined 100 days after the treatment.
  6. # - Resistance to secondary challenge – number of cured mice that were resistant to secondary challenge is shown.
  7. ‡
  8. - Statistical significant difference compared to control group (p < 0.05).
  9. § - Statistical significant difference compared to IR (p < 0.05).
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BMC Cancer

ISSN: 1471-2407

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