Therapeutic index. Radiation dose response curves for local tumor control of SA-1 sarcoma tumors (panel A) and skin reaction (panel B). Arrows indicate response on dry skin desquamation less than 20% (panel A), and radiation doses with which this skin reaction occurs (panel B). In panel A, 7–10 mice per treatment group were evaluated at each dose point. In panel B, 7–10 mice per treatment group were evaluated at each dose and the average of five highest skin reaction scores for each dose used was plotted.