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Table 1 Tumor characterization

From: Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice

Genotype

# of mice

Tumor onset (days)

Specific growth rate

# of tumors at time of death

# of mice with lung metastases

MTB-IGFIR

11

35.5 ± 2.0

0.14 ± 0.02

3.2 ± 0.2

2/11

MTB-IGFIR/Akt1−/−

6

47.3 ± 3.1*

0.07 ± 0.01*

2.8 ± 0.8

1/6

MTB-IGFIR/Akt2−/−

6

43.6 ± 3.6*

0.09 ± 0.02*

3.5 ± 0.6

1/6

  1. *significantly different from WT as determined by a Duncan’s test using WT, Akt1−/− and Akt2−/− mice.
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BMC Cancer

ISSN: 1471-2407

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