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Figure 5 | BMC Cancer

Figure 5

From: Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Figure 5

VLX40 shows in vivo activity in hollow fiber cultures. In A, the antitumoral effect of a single dose of VLX40 was investigated in mice (n = 8 per treatment group) carrying subcutaneous hollow fiber cultures of the myeloid cell line U-937. High and low refers to 2.0 and 0.5 μmol VLX40 per animal, respectively. The results are presented as net growth and expressed as mean value + S.E.M (n = 8). The difference between the high dose and control was statistically significant (p < 0.05, Student’s t-test). In panels B-D the effect of the high dose VLX40 on weight gain (B), red and white blod cell count (C) and hemoglobin and platelet count (D) is shown.

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