Figure 1
From: BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma
Transient loss of BAP1 causes a decrease in proliferation in uveal melanoma cells. (a) Western blot of two uveal melanoma cell lines, 92.1 and Mel290, showing the levels of BAP1 after transient knockdown of BAP1 with two independent siRNAs compared to control siRNA. α-tubulin was used as a loading control (b-c) Cell proliferation of the indicated melanoma cell lines transfected with BAP1 (grey line) or control (black line) siRNA. Proliferation was measured by BrdU incorporation and shown as fold change compared to Day 1 (b) 92.1 cells (c) Mel290 cells.