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Table 3 Sensitivity of hepatocellular carcinoma (HCC) cells to 5-fluorouracil (5-FU) (IC 50 of 5-FU (mg/L)) in different treatment strategies

From: Schedule-dependent antitumor effects of 5-fluorouracil combined with sorafenib in hepatocellular carcinoma

Cell line

F

(S + F)/ p-value (vs. F)

S + F/ p-value (vs. F)

F + S/ p-value (vs. F)

MHCC97H

116.59 ± 62.04

271.63 ± 57.08/p = 0.002

477.46 ± 146.45/p = 0.000

25.45 ± 9.72/p = 0.042

SMMC-7721

47.19 ± 13.02

43.16 ± 8.76/p = 0.948

1371.26 ± 237.70/p = 0.000

9.47 ± 1.03/p = 0.568

  1. S: sorafenib, F: 5-FU.