Table 2 The 15 miRNAs with lowest p -values for differential expression between TZ and PZ in normal prostate tissue and their previously identified differentially expressed target genes
miRNA | +/− | Predicted (validated) target | Noel et al. [20] | Van der Heul-Nieuwenhuijsen et al. [21] |
|---|---|---|---|---|
genes | ||||
miR-433 | + | 880 ( 2 ) | * | NAT1, SRPX, KLK3, EDN3, KIAA1324 |
miR-494 | + | 707 ( 1 ) | DHX9, SYTL2 | PCOLCE, LUM, SRPX, RAB27A, MED28, PCP4, CCL2 |
miR-22* | + | 696 ( 0 ) | * | BAMBI, PFKFB3, RAB10, NEXN, ATF3, FOLH1, CEBPD, SNX25, MED28, LRRC28 |
miR-15a* | - | 664 ( 0 ) | * | PFKFB3, EGR2, EGR1, BIK, KLK3, |
PBEF1, TRPM4, DDX5 | ||||
miR-15b* | - | 669 ( 0 ) | * | NEXN, SRPX, EGR1, HAT1, PBEF1, |
UAP1 | ||||
miR-379 | + | 799 ( 1 ) | S100A4 | C6orf115, GMNN, RBP1, CALD1, ASPA, DBI, ATP2C1, SERPINI1, SRPX, DUSP1, ECM1, RABGGTB, GRP58, TM4SF1, CCL2 |
miR-216b | - | 862 ( 0 ) | HSD11B1 | EAF2, C6orf115, IFNGR1, TFPI2, |
HAT1, PENK, PBEF1, LPHN2, SFRS9 | ||||
miR-181c | - | 990 ( 5 ) | HSD11B1 | GATA6, SFRS5, KCNMA1, FKBP1A, ZFYVE26, KLF6, PRKAG2, THBS4, LPHN2, SPOCK3, EIF4A2, TACSTD2, MYBPC1, TGBR3, RAB3IP, TUBB |
miR-543 | + | 875 ( 0 ) | * | KCNMA1, C6orf115, DACH1, FKBP1A. PRKAG2, SERPINI1, RABGGTB, THBS4, PTGS2, TM4SF1, EIF4A2,SFRS9, KIAA1324, RAB3IP, CCL2 |
miR-27b* | + | 722 ( 0 ) | HSD11B1 | ASPA, MLPH, FBXO2, BRI3, PRRX2, PENK, UAP1, SGCE, TRIM36, EIF4A2, TBCA |
miR-154 | + | 738 ( 0 ) | EFEMP1 | EAF2, TNFSF10, GMNN, CSRP2, |
GCAT, SRPX, FEZ1, SGCE, DDX5 | ||||
miR-424* | + | 535 ( 1 ) | DHX9, HOXD13 | HEPH, C6orf115, FKBP1A, PRKAG2, HPN, ECM1, THBS4, COL16A1, CCL2 |
miR-495 | + | 896 ( 0 ) | * | SFRS5, TACSTD1, C6orf115, JUNB, SERPINI1, MCM2, NANS, DUSP1, CITED2, LIMS2, NIPA2, NDN, PBEF1, TFF1, UAP1, RPRM, CYP1B1, RAB3IP, CCL2 |
miR-337-3p | + | 888 ( 0 ) | SPON1 | NRG2, TRIT1, ATF3, SPON1, CSRP2, |
C15orf5, COL16A1, NDN, LHFP | ||||
miR-127-3p | + | 741 ( 0 ) | C6orf32, NELL2 | XBP1, KCNMA1, FKBP1A, GCAT, GPR30, KCNJ8, TUBGCP2, TFF1, PTGDS, GADD45G |