Cost-effectiveness of MRI for breast cancer screening in BRCA1/2 mutation carriers

BMC Cancer

Table 4 Cost-effectiveness and effectiveness of MRI screening vs. annual mammography alone

Cost-effectiveness*	Mammography only		MRI& mammography		Increment
	Mean	95% CI	Mean	95% CI	Mean	95% CI
Cost ($)	5,201	3,303-7,911	9,893	7,459-12,942	4,692	3,084-6,504
QALYs	22.57	21.86-22.75	22.66	21.85-22.83	0.092	−0.027-0.190
C/E ($/QALY)	231	146-351	437	329-572	50,911	Dominated-213,794
Screening effectiveness†	Mammography only		MRI & mammography
Screening effectiveness†	Mean (%)	95% CI	Mean (%)	95% CI
Incidence	42.7	38.8-46.7	42.7	38.7-46.7
Program sensitivity‡	71.7	65.9-77.2	93.9	89.4-97.3
Stage distribution
In Situ	20.8	12.8-30.1	18.2	12.8-24.2
Local	48.7	39.1-58.3	61	53.8-67.8
Regional	26.9	19.6-35.5	19.1	13.9-25.1
Distant	3.6	2-7.2	1.7	0.6-3.8
Survival	79.1	77.4-80.4	80.1	78.9-81.1

Abbreviations: MRI magnetic resonance imaging, QALY quality-adjusted life year.
* Costs and utilities discounted at 3.5% per year.
† Calculated at end of MRI plus mammography screening program (age 65 years).
‡ Proportion of cancers in model detected by screening; all screen-detected cancers (true positives) divided by all incident cancers.

ISSN: 1471-2407