Skip to main content

Table 4 Cost-effectiveness and effectiveness of MRI screening vs. annual mammography alone

From: Cost-effectiveness of MRI for breast cancer screening in BRCA1/2 mutation carriers

Cost-effectiveness* Mammography only MRI& mammography Increment
  Mean 95% CI Mean 95% CI Mean 95% CI
 Cost ($) 5,201 3,303-7,911 9,893 7,459-12,942 4,692 3,084-6,504
 QALYs 22.57 21.86-22.75 22.66 21.85-22.83 0.092 −0.027-0.190
 C/E ($/QALY) 231 146-351 437 329-572 50,911 Dominated-213,794
Screening effectiveness† Mammography only MRI & mammography  
Mean (%) 95% CI Mean (%) 95% CI  
Incidence 42.7 38.8-46.7 42.7 38.7-46.7  
Program sensitivity‡ 71.7 65.9-77.2 93.9 89.4-97.3  
Stage distribution
 In Situ 20.8 12.8-30.1 18.2 12.8-24.2  
 Local 48.7 39.1-58.3 61 53.8-67.8  
 Regional 26.9 19.6-35.5 19.1 13.9-25.1  
 Distant 3.6 2-7.2 1.7 0.6-3.8  
Survival 79.1 77.4-80.4 80.1 78.9-81.1  
  1. Abbreviations: MRI magnetic resonance imaging, QALY quality-adjusted life year.
  2. * Costs and utilities discounted at 3.5% per year.
  3. † Calculated at end of MRI plus mammography screening program (age 65 years).
  4. ‡ Proportion of cancers in model detected by screening; all screen-detected cancers (true positives) divided by all incident cancers.