From: Cost-effectiveness of MRI for breast cancer screening in BRCA1/2 mutation carriers
Cost-effectiveness* | Mammography only | MRI& mammography | Increment | |||
---|---|---|---|---|---|---|
Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | |
Cost ($) | 5,201 | 3,303-7,911 | 9,893 | 7,459-12,942 | 4,692 | 3,084-6,504 |
QALYs | 22.57 | 21.86-22.75 | 22.66 | 21.85-22.83 | 0.092 | −0.027-0.190 |
C/E ($/QALY) | 231 | 146-351 | 437 | 329-572 | 50,911 | Dominated-213,794 |
Screening effectiveness† | Mammography only | MRI & mammography | ||||
Mean (%) | 95% CI | Mean (%) | 95% CI | |||
Incidence | 42.7 | 38.8-46.7 | 42.7 | 38.7-46.7 | ||
Program sensitivity‡ | 71.7 | 65.9-77.2 | 93.9 | 89.4-97.3 | ||
Stage distribution | ||||||
In Situ | 20.8 | 12.8-30.1 | 18.2 | 12.8-24.2 | ||
Local | 48.7 | 39.1-58.3 | 61 | 53.8-67.8 | ||
Regional | 26.9 | 19.6-35.5 | 19.1 | 13.9-25.1 | ||
Distant | 3.6 | 2-7.2 | 1.7 | 0.6-3.8 | ||
Survival | 79.1 | 77.4-80.4 | 80.1 | 78.9-81.1 |