Screening and diagnostics
| |
95% CI
|
---|
MRI screening*
|
1.000
|
-
|
Mammography
|
1.000
|
-
|
Diagnostic workup
|
0.987
|
0.761-1.00
|
Treatment†
|
In situ
|
0.965
|
0.463-1.00
|
Localized
|
0.860
|
0.330-1.00
|
Regional
|
0.675
|
0.315-0.929
|
Distant
|
0.380
|
0.211-0.564
|
Progression (end of life)
|
0.380
|
0.211-0.564
|
Remission
|
0.965
|
0.463-1.00
|
Dead
|
0.000
|
-
|
Well
|
1.000
|
-
|
- Abbreviations: CI Confidence interval.
- * Full utility (1.00) assumed for screening states and ‘Well’ state; not varied in probabilistic sensitivity analysis.
- † Treatment utilities by stage at diagnosis applied for 18 months, after which ‘Remission’ value applied until progression and death or transition to ‘Well,’ 10-yrs post-diagnosis; utilities for localized, regional, distant disease, and disease progression states were derived from Schleinitz et al.[38], and utility for diagnostic work-up, remission and in situ disease were from Bonomi et al.[39].