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Figure 5 | BMC Cancer

Figure 5

From: Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases

Figure 5

Quantification of the B16-F10 lung metastases using dosage of MITF melanocyte specific transcription factor expression . (a) Branched DNA analysis of RNA extracted from wild-type or B16-F10 tumor-bearing lungs for determination of MITF transcription factor mRNA expression level. (b) MITF RNA level was analyzed by branched DNA in B16-F10 tumor-bearing lungs untreated (control) or after a systemic treatment with survivin and cyclin B1 or negative control ssiRNA delivered with in vivo-JetPEI® (1 mg/kg, N/P=12.5). n = 6 to 9 animals per group. P values were calculated; * p<0.05; ***p<0.001.

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BMC Cancer

ISSN: 1471-2407

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