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Table 1 Comparison of demographic data, comorbidities, and laboratory data between cryptogenic hepatocellular carcinoma (HCC) patients and patients with HCC associated with hepatitis B virus infection, hepatitis C virus infection, and alcohol

From: Clinical features and outcome of cryptogenic hepatocellular carcinoma compared to those of viral and alcoholic hepatocellular carcinoma

  Cryptogenic HCC (n = 35) HBV-HCC * p HCV-HCC **p ALC-HCC ***p
   (n = 321)   (n = 69)   (n = 55)  
Age, yr† 68.3 ± 10.5 57.1 ± 10.3 <0.001 68.1 ± 9.0 0.896 65.5 ± 10.0 0.164
Gender, Male†† 20 (57.1) 244 (76.0) 0.015 44 (63.8) 0.512 51 (92.7) <0.001
BMI (kg/m2) † 24.6 ± 3.3 23.4 ± 3.4 0.034 22.2 ± 3.9 0.002 24.0 ± 4.3 0.143
Obesity†† 16 (45.7) 85 (26.7) 0.018 13 (18.8) 0.004 12 (21.8) 0.017
Diabetes †† 13 (37.1) 55 (17.1) 0.004 17 (24.6) 0.183 19 (34.5) 0.802
Hypertension †† 20 (57.1) 77 (24.0) <0.001 32 (46.4) 0.299 18 (32.7) 0.022
Hyperlipidemia†† 9 (25.7) 10 (3.1) <0.001 4 (5.8) 0.004 2 (3.6) 0.003
Follow-up period, mo† 26.1 ± 27.8 28.5 ± 27.0 0.573 29.9 ± 25.1 0.362 29.2 ± 25.6 0.518
Albumin (g/dL) † 3.7 ± 0.5 3.8 ± 0.6 0.346 3.7 ± 0.6 0.780 3.7 ± 0.5 0.545
Bilirubin (mg/dL) † 1.2 ± 0.7 1.6 ± 2.4 0.437 1.8 ± 2.7 0.551 1.6 ± 1.9 0.216
ALP (IU/L) † 123.3 ± 73.3 137.2 ± 97.2 0.555 125.2 ± 63.1 0.728 132.6 ± 91.8 0.855
AST (IU/L) † 83.8 ± 165.4 89.3 ± 140.5 0.342 111.9 ± 114.6 <0.001 53.2 ± 31.9 0.419
ALT (IU/L) † 58.7 ± 99.0 64.4 ± 98.4 0.111 78.6 ± 60.6 0.001 47.4 ± 72.7 0.371
Platelet (103/μL) †† (<10/10 ~ 13/>13) 5/7/23 87/50/182 0.157 19/18/32 0.056 14/9/42 0.263
PT-INR† 1.14 ± 0.16 1.15 ± 0.18 0.897 1.15 ± 0.14 0.791 1.14 ± 0.19 0.593
Hemoglobin (g/dL) † 12.6 ± 2.3 13.6 ± 2.0 0.007 12.8 ± 2.1 0.570 13.1 ± 2.2 0.460
Na (mmol/L) † 137.0 ± 8.8 137.4 ± 9.6 0.551 137.7 ± 4.0 0.535 137.9 ± 3.4 0.340
Creatinine (mg/dL) † 0.9 ± 0.2 1.0 ± 0.3 0.738 1.2 ± 1.0 0.040 1.2 ± 1.0 0.537
C-P class (A/BC) †† 29/6 246/75 0.404 50/19 0.241 40/15 0.268
MELD score† 9.0 ± 2.9 9.6 ± 3.2 0.273 10.2 ± 3.7 0.076 10.5 ± 4.3 0.051
  1. †Expressed as the mean ± standard deviation. ††Expressed as the number of subjects (%).
  2. Values in bold, statistically significant (p < 0.05).
  3. BMI, Body mass index; AST, Aspartate transaminase; ALT, Alanine transaminase; PT-INR, Prothrombin time-international normalized ratio; C-P class, Child-Pugh class; MELD, Model for end-stage liver disease; HBV-HCC, Hepatitis B-associated hepatocellular carcinoma; HCV-HCC, Hepatitis C-associated hepatocellular carcinoma; ALC-HCC, Alcohol-associated hepatocellular carcinoma.
  4. *p: Cryptogenic HCC vs. HBV-HCC.
  5. **p: Cryptogenic HCC vs. HCV-HCC.
  6. ***p: Cryptogenic HCC vs. ALC-HCC.