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Table 3 Ratios R anox and R hypox for all tested drugs in all cell lines

From: Effects of hypoxia on human cancer cell line chemosensitivity

  A2780 ACHN H69 MCF-7 U-937
  Anoxia Hypoxia Anoxia Hypoxia Anoxia Hypoxia Anoxia Hypoxia Anoxia Hypoxia
5-FU 0.29*** N/A N/A N/A N/A N/A N/A N/A 1.7** 1.5
Acriflavine 0.56 N/A 2.4* 1.0 0.19** 0.23** N/A 0.52 0.99 0.81*
Bortezomib 0.10*** 0.20*** >4.0** >6.0** 0.14** 0.76 N/A N/A 1.1 0.85
Cisplatin 1.6 0.90 3.6** 1.1 0.22** 0.21** 0.37*** 0.49** 0.52*** 0.43***
Digitoxin 3.6 0.94 N/A >133** <0.050 <0.56 N/A N/A 2.0 0.95
Digoxin 2.4 1.1 N/A >80** N/A <0.24 N/A N/A 1.2 0.85
Docetaxel 2.3 1.0 44*** 7.3** 1.0 1.8 0.75 0.58 N/A N/A
Doxorubicin 1.3 0.50 3.5** 1.1 1.1 <0.46 >2.1* 0.59* 0.69* 0.61**
Etoposide 1.3 0.73 >3.7** >6.5** 0.46* 0.75 N/A N/A 0.87 0.80*
Gemcitabine N/A 0.62 N/A N/A N/A N/A N/A N/A N/A N/A
Irinotecan 1.3 1.3 5.3*** >2.7** 0.32 N/A >2.7 N/A 1.1 0.86
Melphalan 2.0 2.6 4.9*** 5.1** 0.24** N/A 0.89 N/A 0.61** 0.55**
Mitomycin C 0.17*** 0.22 1.1 2.0** 0.11*** 0.18** 0.63* 0.31*** 0.45*** 0.44***
Rapamycin 1.2 0.34 1.2 1.3 0.14** 0.08** N/A N/A 0.34* 1.8
Sorafenib 0.85 0.87 1.6* 1.2 0.58 1.8 1.5 1.4 2.0 1.2
Thalidomide N/A N/A N/A N/A <0.89* N/A <0.28 N/A 0.21*** <0.44*
Tirapazamine 0.044*** 0.045*** 0.1*** 0.10*** 0.025*** 0.042*** 0.055*** 0.062*** 0.072*** 0.094***
Topotecan 0.023*** 0.50 N/A 1.5 N/A 0.31** N/A N/A 2.2* 0.72
Vincristine 5.0** 0.010 N/A N/A N/A N/A N/A N/A N/A >1
  1. Ranox = anoxic IC50/normoxic IC50 and Rhypox = hypoxic IC50/normoxic IC50. Ratio value for a drug: 0.8-1.2 = equally effective in anoxia/hypoxia and normoxia, <0.8 = more effective in anoxia/hypoxia, >1.2 = more effective in normoxia, N/A = not applicable. Significance levels * p < 0.05; ** p < 0.01; *** p < 0.001; two-tailed t-test.