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Table 3 Ratios R anox and R hypox for all tested drugs in all cell lines

From: Effects of hypoxia on human cancer cell line chemosensitivity

 

A2780

ACHN

H69

MCF-7

U-937

 

Anoxia

Hypoxia

Anoxia

Hypoxia

Anoxia

Hypoxia

Anoxia

Hypoxia

Anoxia

Hypoxia

5-FU

0.29***

N/A

N/A

N/A

N/A

N/A

N/A

N/A

1.7**

1.5

Acriflavine

0.56

N/A

2.4*

1.0

0.19**

0.23**

N/A

0.52

0.99

0.81*

Bortezomib

0.10***

0.20***

>4.0**

>6.0**

0.14**

0.76

N/A

N/A

1.1

0.85

Cisplatin

1.6

0.90

3.6**

1.1

0.22**

0.21**

0.37***

0.49**

0.52***

0.43***

Digitoxin

3.6

0.94

N/A

>133**

<0.050

<0.56

N/A

N/A

2.0

0.95

Digoxin

2.4

1.1

N/A

>80**

N/A

<0.24

N/A

N/A

1.2

0.85

Docetaxel

2.3

1.0

44***

7.3**

1.0

1.8

0.75

0.58

N/A

N/A

Doxorubicin

1.3

0.50

3.5**

1.1

1.1

<0.46

>2.1*

0.59*

0.69*

0.61**

Etoposide

1.3

0.73

>3.7**

>6.5**

0.46*

0.75

N/A

N/A

0.87

0.80*

Gemcitabine

N/A

0.62

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

Irinotecan

1.3

1.3

5.3***

>2.7**

0.32

N/A

>2.7

N/A

1.1

0.86

Melphalan

2.0

2.6

4.9***

5.1**

0.24**

N/A

0.89

N/A

0.61**

0.55**

Mitomycin C

0.17***

0.22

1.1

2.0**

0.11***

0.18**

0.63*

0.31***

0.45***

0.44***

Rapamycin

1.2

0.34

1.2

1.3

0.14**

0.08**

N/A

N/A

0.34*

1.8

Sorafenib

0.85

0.87

1.6*

1.2

0.58

1.8

1.5

1.4

2.0

1.2

Thalidomide

N/A

N/A

N/A

N/A

<0.89*

N/A

<0.28

N/A

0.21***

<0.44*

Tirapazamine

0.044***

0.045***

0.1***

0.10***

0.025***

0.042***

0.055***

0.062***

0.072***

0.094***

Topotecan

0.023***

0.50

N/A

1.5

N/A

0.31**

N/A

N/A

2.2*

0.72

Vincristine

5.0**

0.010

N/A

N/A

N/A

N/A

N/A

N/A

N/A

>1

  1. Ranox = anoxic IC50/normoxic IC50 and Rhypox = hypoxic IC50/normoxic IC50. Ratio value for a drug: 0.8-1.2 = equally effective in anoxia/hypoxia and normoxia, <0.8 = more effective in anoxia/hypoxia, >1.2 = more effective in normoxia, N/A = not applicable. Significance levels * p < 0.05; ** p < 0.01; *** p < 0.001; two-tailed t-test.