TY - JOUR AU - Durand, R. E. AU - Raleigh, J. A. PY - 1998 DA - 1998// TI - Identification of nonproliferating but viable hypoxic tumor cells in vivo JO - Cancer Res VL - 58 ID - Durand1998 ER - TY - JOUR AU - Evans, S. M. AU - Joiner, B. AU - Jenkins, W. T. AU - Laughlin, K. M. AU - Lord, E. M. AU - Koch, C. J. PY - 1995 DA - 1995// TI - Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] JO - Br J Cancer VL - 72 UR - https://doi.org/10.1038/bjc.1995.427 DO - 10.1038/bjc.1995.427 ID - Evans1995 ER - TY - JOUR AU - Partridge, S. E. AU - Aquino-Parsons, C. AU - Luo, C. AU - Green, A. AU - Olive, P. L. PY - 2001 DA - 2001// TI - A pilot study comparing intratumoral oxygenation using the comet assay following 2.5% and 5% carbogen and 100% oxygen JO - Int J Radiat Oncol Biol Phys VL - 49 UR - https://doi.org/10.1016/S0360-3016(00)01504-2 DO - 10.1016/S0360-3016(00)01504-2 ID - Partridge2001 ER - TY - JOUR AU - Tannock, I. F. PY - 1968 DA - 1968// TI - The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour JO - Br J Cancer VL - 22 UR - https://doi.org/10.1038/bjc.1968.34 DO - 10.1038/bjc.1968.34 ID - Tannock1968 ER - TY - JOUR AU - Evans, S. M. AU - Hahn, S. M. AU - Magarelli, D. P. AU - Koch, C. J. PY - 2001 DA - 2001// TI - Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation JO - Am J Clin Oncol VL - 24 UR - https://doi.org/10.1097/00000421-200110000-00011 DO - 10.1097/00000421-200110000-00011 ID - Evans2001 ER - TY - JOUR AU - Hanahan, D. AU - Folkman, J. PY - 1996 DA - 1996// TI - Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis JO - Cell VL - 86 UR - https://doi.org/10.1016/S0092-8674(00)80108-7 DO - 10.1016/S0092-8674(00)80108-7 ID - Hanahan1996 ER - TY - JOUR AU - Zetter, B. R. PY - 1998 DA - 1998// TI - Angiogenesis and tumor metastasis JO - Annu Rev Med VL - 49 UR - https://doi.org/10.1146/annurev.med.49.1.407 DO - 10.1146/annurev.med.49.1.407 ID - Zetter1998 ER - TY - JOUR AU - Brahimi-Horn, M. C. AU - Chiche, J. AU - Pouyssegur, J. PY - 2007 DA - 2007// TI - Hypoxia and cancer JO - J Mol Med VL - 85 UR - https://doi.org/10.1007/s00109-007-0281-3 DO - 10.1007/s00109-007-0281-3 ID - Brahimi-Horn2007 ER - TY - JOUR AU - Hicklin, D. J. AU - Ellis, L. M. PY - 2005 DA - 2005// TI - Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis JO - J Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.06.081 DO - 10.1200/JCO.2005.06.081 ID - Hicklin2005 ER - TY - JOUR AU - Zhou, J. AU - Schmid, T. AU - Schnitzer, S. AU - Brune, B. PY - 2006 DA - 2006// TI - Tumor hypoxia and cancer progression JO - Cancer Lett VL - 237 UR - https://doi.org/10.1016/j.canlet.2005.05.028 DO - 10.1016/j.canlet.2005.05.028 ID - Zhou2006 ER - TY - JOUR AU - Vander Heiden, M. G. AU - Cantley, L. C. AU - Thompson, C. B. PY - 2009 DA - 2009// TI - Understanding the Warburg effect: the metabolic requirements of cell proliferation JO - Science VL - 324 UR - https://doi.org/10.1126/science.1160809 DO - 10.1126/science.1160809 ID - Vander Heiden2009 ER - TY - JOUR AU - Cardone, R. A. AU - Casavola, V. AU - Reshkin, S. J. PY - 2005 DA - 2005// TI - The role of disturbed pH dynamics and the Na+/H + exchanger in metastasis JO - Nat Rev Cancer VL - 5 UR - https://doi.org/10.1038/nrc1713 DO - 10.1038/nrc1713 ID - Cardone2005 ER - TY - JOUR AU - Bogenrieder, T. AU - Herlyn, M. PY - 2003 DA - 2003// TI - Axis of evil: molecular mechanisms of cancer metastasis JO - Oncogene VL - 22 UR - https://doi.org/10.1038/sj.onc.1206757 DO - 10.1038/sj.onc.1206757 ID - Bogenrieder2003 ER - TY - JOUR AU - Grau, C. AU - Khalil, A. A. AU - Nordsmark, M. AU - Horsman, M. R. AU - Overgaard, J. PY - 1994 DA - 1994// TI - The relationship between carbon monoxide breathing, tumour oxygenation and local tumour control in the C3H mammary carcinoma in vivo JO - Br J Cancer VL - 69 UR - https://doi.org/10.1038/bjc.1994.8 DO - 10.1038/bjc.1994.8 ID - Grau1994 ER - TY - JOUR AU - Brizel, D. M. AU - Dodge, R. K. AU - Clough, R. W. AU - Dewhirst, M. W. PY - 1999 DA - 1999// TI - Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome JO - Radiother Oncol VL - 53 UR - https://doi.org/10.1016/S0167-8140(99)00102-4 DO - 10.1016/S0167-8140(99)00102-4 ID - Brizel1999 ER - TY - JOUR AU - Hockel, M. AU - Schlenger, K. AU - Aral, B. AU - Mitze, M. AU - Schaffer, U. AU - Vaupel, P. PY - 1996 DA - 1996// TI - Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix JO - Cancer Res VL - 56 ID - Hockel1996 ER - TY - JOUR AU - Bodner, G. AU - Schocke, M. F. AU - Rachbauer, F. AU - Seppi, K. AU - Peer, S. AU - Fierlinger, A. AU - Sununu, T. AU - Jaschke, W. R. PY - 2002 DA - 2002// TI - Differentiation of malignant and benign musculoskeletal tumors: combined color and power Doppler US and spectral wave analysis JO - Radiology VL - 223 UR - https://doi.org/10.1148/radiol.2232010406 DO - 10.1148/radiol.2232010406 ID - Bodner2002 ER - TY - JOUR AU - Brown, J. M. AU - Giaccia, A. J. PY - 1998 DA - 1998// TI - The unique physiology of solid tumors: opportunities (and problems) for cancer therapy JO - Cancer Res VL - 58 ID - Brown1998 ER - TY - JOUR AU - Graeber, T. G. AU - Osmanian, C. AU - Jacks, T. AU - Housman, D. E. AU - Koch, C. J. AU - Lowe, S. W. AU - Giaccia, A. J. PY - 1996 DA - 1996// TI - Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours JO - Nature VL - 379 UR - https://doi.org/10.1038/379088a0 DO - 10.1038/379088a0 ID - Graeber1996 ER - TY - JOUR AU - Brown, J. M. AU - Wilson, W. R. PY - 2004 DA - 2004// TI - Exploiting tumour hypoxia in cancer treatment JO - Nat Rev Cancer VL - 4 UR - https://doi.org/10.1038/nrc1367 DO - 10.1038/nrc1367 ID - Brown2004 ER - TY - JOUR AU - Roninson, I. B. PY - 1992 DA - 1992// TI - The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo JO - Biochem Pharmacol VL - 43 UR - https://doi.org/10.1016/0006-2952(92)90666-7 DO - 10.1016/0006-2952(92)90666-7 ID - Roninson1992 ER - TY - JOUR AU - Wartenberg, M. AU - Ling, F. C. AU - Muschen, M. AU - Klein, F. AU - Acker, H. AU - Gassmann, M. AU - Petrat, K. AU - Putz, V. AU - Hescheler, J. AU - Sauer, H. PY - 2003 DA - 2003// TI - Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species JO - FASEB J VL - 17 ID - Wartenberg2003 ER - TY - JOUR AU - Matzow, T. AU - Cowen, R. L. AU - Williams, K. J. AU - Telfer, B. A. AU - Flint, P. J. AU - Southgate, T. D. AU - Saunders, M. P. PY - 2007 DA - 2007// TI - Hypoxia-targeted over-expression of carboxylesterase as a means of increasing tumour sensitivity to irinotecan (CPT-11) JO - J Gene Med VL - 9 UR - https://doi.org/10.1002/jgm.1016 DO - 10.1002/jgm.1016 ID - Matzow2007 ER - TY - JOUR AU - Erler, J. T. AU - Cawthorne, C. J. AU - Williams, K. J. AU - Koritzinsky, M. AU - Wouters, B. G. AU - Wilson, C. AU - Miller, C. AU - Demonacos, C. AU - Stratford, I. J. AU - Dive, C. PY - 2004 DA - 2004// TI - Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance JO - Mol Cell Biol VL - 24 UR - https://doi.org/10.1128/MCB.24.7.2875-2889.2004 DO - 10.1128/MCB.24.7.2875-2889.2004 ID - Erler2004 ER - TY - JOUR AU - Lash, G. E. AU - Fitzpatrick, T. E. AU - Graham, C. H. PY - 2001 DA - 2001// TI - Effect of hypoxia on cellular adhesion to vitronectin and fibronectin JO - Biochem Biophys Res Commun VL - 287 UR - https://doi.org/10.1006/bbrc.2001.5618 DO - 10.1006/bbrc.2001.5618 ID - Lash2001 ER - TY - JOUR AU - Kim, J. Y. AU - Kim, Y. J. AU - Lee, S. AU - Park, J. H. PY - 2009 DA - 2009// TI - The critical role of ERK in death resistance and invasiveness of hypoxia-selected glioblastoma cells JO - BMC Cancer VL - 9 UR - https://doi.org/10.1186/1471-2407-9-27 DO - 10.1186/1471-2407-9-27 ID - Kim2009 ER - TY - JOUR AU - Carmeliet, P. AU - Dor, Y. AU - Herbert, J. M. AU - Fukumura, D. AU - Brusselmans, K. AU - Dewerchin, M. AU - Neeman, M. AU - Bono, F. AU - Abramovitch, R. AU - Maxwell, P. AU - Koch, C. J. AU - Ratcliffe, P. AU - Moons, L. AU - Jain, R. K. AU - Collen, D. AU - Keshert, E. PY - 1998 DA - 1998// TI - Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis JO - Nature VL - 394 UR - https://doi.org/10.1038/28867 DO - 10.1038/28867 ID - Carmeliet1998 ER - TY - JOUR AU - Griguer, C. E. AU - Oliva, C. R. AU - Kelley, E. E. AU - Giles, G. I. AU - Lancaster, J. R. AU - Gillespie, G. Y. PY - 2006 DA - 2006// TI - Xanthine oxidase-dependent regulation of hypoxia-inducible factor in cancer cells JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-3364 DO - 10.1158/0008-5472.CAN-05-3364 ID - Griguer2006 ER - TY - JOUR AU - Baumann, R. P. AU - Penketh, P. G. AU - Seow, H. A. AU - Shyam, K. AU - Sartorelli, A. C. PY - 2008 DA - 2008// TI - Generation of oxygen deficiency in cell culture using a two-enzyme system to evaluate agents targeting hypoxic tumor cells JO - Radiat Res VL - 170 UR - https://doi.org/10.1667/RR1431.1 DO - 10.1667/RR1431.1 ID - Baumann2008 ER - TY - JOUR AU - Minchinton, A. I. AU - Tannock, I. F. PY - 2006 DA - 2006// TI - Drug penetration in solid tumours JO - Nat Rev Cancer VL - 6 UR - https://doi.org/10.1038/nrc1893 DO - 10.1038/nrc1893 ID - Minchinton2006 ER - TY - JOUR AU - Karlsson, H. AU - Fryknas, M. AU - Larsson, R. AU - Nygren, P. PY - 2012 DA - 2012// TI - Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system JO - Exp Cell Res VL - 318 UR - https://doi.org/10.1016/j.yexcr.2012.03.026 DO - 10.1016/j.yexcr.2012.03.026 ID - Karlsson2012 ER - TY - JOUR AU - Hirschhaeuser, F. AU - Menne, H. AU - Dittfeld, C. AU - West, J. AU - Mueller-Klieser, W. AU - Kunz-Schughart, L. A. PY - 2010 DA - 2010// TI - Multicellular tumor spheroids: an underestimated tool is catching up again JO - J Biotechnol VL - 148 UR - https://doi.org/10.1016/j.jbiotec.2010.01.012 DO - 10.1016/j.jbiotec.2010.01.012 ID - Hirschhaeuser2010 ER - TY - JOUR AU - Danielsen, T. AU - Skoyum, R. AU - Rofstad, E. K. PY - 1997 DA - 1997// TI - Hypoxia-induced changes in radiation sensitivity in human melanoma cells: importance of oxygen-regulated proteins, adenylate energy charge and cell cycle distribution JO - Radiother Oncol VL - 44 UR - https://doi.org/10.1016/S0167-8140(97)01929-4 DO - 10.1016/S0167-8140(97)01929-4 ID - Danielsen1997 ER - TY - JOUR AU - Yang, S. J. AU - Pyen, J. AU - Lee, I. AU - Lee, H. AU - Kim, Y. AU - Kim, T. PY - 2004 DA - 2004// TI - Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells JO - J Biochem Mol Biol VL - 37 UR - https://doi.org/10.5483/BMBRep.2004.37.4.480 DO - 10.5483/BMBRep.2004.37.4.480 ID - Yang2004 ER - TY - JOUR AU - Koch, S. AU - Mayer, F. AU - Honecker, F. AU - Schittenhelm, M. AU - Bokemeyer, C. PY - 2003 DA - 2003// TI - Efficacy of cytotoxic agents used in the treatment of testicular germ cell tumours under normoxic and hypoxic conditions in vitro JO - Br J Cancer VL - 89 UR - https://doi.org/10.1038/sj.bjc.6601375 DO - 10.1038/sj.bjc.6601375 ID - Koch2003 ER - TY - JOUR AU - Hay, M. P. AU - Gamage, S. A. AU - Kovacs, M. S. AU - Pruijn, F. B. AU - Anderson, R. F. AU - Patterson, A. V. AU - Wilson, W. R. AU - Brown, J. M. AU - Denny, W. A. PY - 2003 DA - 2003// TI - Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine JO - J Med Chem VL - 46 UR - https://doi.org/10.1021/jm020367+ DO - 10.1021/jm020367+ ID - Hay2003 ER - TY - JOUR AU - Sakata, K. AU - Kwok, T. T. AU - Murphy, B. J. AU - Laderoute, K. R. AU - Gordon, G. R. AU - Sutherland, R. M. PY - 1991 DA - 1991// TI - Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance JO - Br J Cancer VL - 64 UR - https://doi.org/10.1038/bjc.1991.405 DO - 10.1038/bjc.1991.405 ID - Sakata1991 ER - TY - JOUR AU - Rohwer, N. AU - Dame, C. AU - Haugstetter, A. AU - Wiedenmann, B. AU - Detjen, K. AU - Schmitt, C. A. AU - Cramer, T. PY - 2010 DA - 2010// TI - Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB JO - PLoS One VL - 5 UR - https://doi.org/10.1371/journal.pone.0012038 DO - 10.1371/journal.pone.0012038 ID - Rohwer2010 ER - TY - JOUR AU - Lee, K. AU - Zhang, H. AU - Qian, D. Z. AU - Rey, S. AU - Liu, J. O. AU - Semenza, G. L. PY - 2009 DA - 2009// TI - Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization JO - Proc Natl Acad Sci USA VL - 106 UR - https://doi.org/10.1073/pnas.0909353106 DO - 10.1073/pnas.0909353106 ID - Lee2009 ER - TY - JOUR AU - Roccaro, A. M. AU - Hideshima, T. AU - Raje, N. AU - Kumar, S. AU - Ishitsuka, K. AU - Yasui, H. AU - Shiraishi, N. AU - Ribatti, D. AU - Nico, B. AU - Vacca, A. AU - Dammacco, F. AU - Richardson, P. G. AU - Anderson, K. C. PY - 2006 DA - 2006// TI - Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-1195 DO - 10.1158/0008-5472.CAN-05-1195 ID - Roccaro2006 ER - TY - JOUR AU - Shin, D. H. AU - Chun, Y. S. AU - Lee, D. S. AU - Huang, L. E. AU - Park, J. W. PY - 2008 DA - 2008// TI - Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1 JO - Blood VL - 111 UR - https://doi.org/10.1182/blood-2007-11-120576 DO - 10.1182/blood-2007-11-120576 ID - Shin2008 ER - TY - JOUR AU - Duyndam, M. C. AU - van Berkel, M. P. AU - Dorsman, J. C. AU - Rockx, D. A. AU - Pinedo, H. M. AU - Boven, E. PY - 2007 DA - 2007// TI - Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells JO - Biochem Pharmacol VL - 74 UR - https://doi.org/10.1016/j.bcp.2007.04.003 DO - 10.1016/j.bcp.2007.04.003 ID - Duyndam2007 ER - TY - JOUR AU - Zhang, H. AU - Qian, D. Z. AU - Tan, Y. S. AU - Lee, K. AU - Gao, P. AU - Ren, Y. R. AU - Rey, S. AU - Hammers, H. AU - Chang, D. AU - Pili, R. AU - Dang, C. V. AU - Liu, J. O. AU - Semenza, G. L. PY - 2008 DA - 2008// TI - Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth JO - Proc Natl Acad Sci USA VL - 105 UR - https://doi.org/10.1073/pnas.0809763105 DO - 10.1073/pnas.0809763105 ID - Zhang2008 ER - TY - JOUR AU - Escuin, D. AU - Kline, E. R. AU - Giannakakou, P. PY - 2005 DA - 2005// TI - Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-4095 DO - 10.1158/0008-5472.CAN-04-4095 ID - Escuin2005 ER - TY - JOUR AU - Forde, J. C. AU - Perry, A. S. AU - Brennan, K. AU - Martin, L. M. AU - Lawler, M. P. AU - Lynch, T. H. AU - Hollywood, D. AU - Marignol, L. PY - 2010 DA - 2010// TI - Docetaxel maintains its cytotoxic activity under hypoxic conditions in prostate cancer cells JO - Urol Oncol VL - 30 UR - https://doi.org/10.1016/j.urolonc.2010.08.015 DO - 10.1016/j.urolonc.2010.08.015 ID - Forde2010 ER - TY - JOUR AU - Kennedy, K. A. AU - Siegfried, J. M. AU - Sartorelli, A. C. AU - Tritton, T. R. PY - 1983 DA - 1983// TI - Effects of anthracyclines on oxygenated and hypoxic tumor cells JO - Cancer Res VL - 43 ID - Kennedy1983 ER - TY - JOUR AU - Sermeus, A. AU - Cosse, J. P. AU - Crespin, M. AU - Mainfroid, V. AU - de Longueville, F. AU - Ninane, N. AU - Raes, M. AU - Remacle, J. AU - Michiels, C. PY - 2008 DA - 2008// TI - Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity JO - Mol Cancer VL - 7 UR - https://doi.org/10.1186/1476-4598-7-27 DO - 10.1186/1476-4598-7-27 ID - Sermeus2008 ER - TY - JOUR AU - Sullivan, R. AU - Graham, C. H. PY - 2009 DA - 2009// TI - Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1 JO - Mol Cancer Ther VL - 8 UR - https://doi.org/10.1158/1535-7163.MCT-08-1090 DO - 10.1158/1535-7163.MCT-08-1090 ID - Sullivan2009 ER - TY - JOUR AU - Onozuka, H. AU - Tsuchihara, K. AU - Esumi, H. PY - 2011 DA - 2011// TI - Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs JO - Cancer Sci VL - 102 UR - https://doi.org/10.1111/j.1349-7006.2011.01880.x DO - 10.1111/j.1349-7006.2011.01880.x ID - Onozuka2011 ER - TY - JOUR AU - Kasuya, K. AU - Tsuchida, A. AU - Nagakawa, Y. AU - Suzuki, M. AU - Abe, Y. AU - Itoi, T. AU - Serizawa, H. AU - Nagao, T. AU - Shimazu, M. AU - Aoki, T. PY - 2011 DA - 2011// TI - Hypoxia-inducible factor-1alpha expression and gemcitabine chemotherapy for pancreatic cancer JO - Oncol Rep VL - 26 ID - Kasuya2011 ER - TY - JOUR AU - Kamiyama, H. AU - Takano, S. AU - Tsuboi, K. AU - Matsumura, A. PY - 2005 DA - 2005// TI - Anti-angiogenic effects of SN38 (active metabolite of irinotecan): inhibition of hypoxia-inducible factor 1 alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) expression of glioma and growth of endothelial cells JO - J Cancer Res Clin Oncol VL - 131 UR - https://doi.org/10.1007/s00432-004-0642-z DO - 10.1007/s00432-004-0642-z ID - Kamiyama2005 ER - TY - JOUR AU - de Wilt, J. H. AU - Manusama, E. R. AU - van Tiel, S. T. AU - van Ijken, M. G. AU - ten Hagen, T. L. AU - Eggermont, A. M. PY - 1999 DA - 1999// TI - Prerequisites for effective isolated limb perfusion using tumour necrosis factor alpha and melphalan in rats JO - Br J Cancer VL - 80 UR - https://doi.org/10.1038/sj.bjc.6690335 DO - 10.1038/sj.bjc.6690335 ID - de Wilt1999 ER - TY - JOUR AU - Hu, Y. AU - Kirito, K. AU - Yoshida, K. AU - Mitsumori, T. AU - Nakajima, K. AU - Nozaki, Y. AU - Hamanaka, S. AU - Nagashima, T. AU - Kunitama, M. AU - Sakoe, K. AU - Komatsu, N. PY - 2009 DA - 2009// TI - Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan JO - Mol Cancer Ther VL - 8 UR - https://doi.org/10.1158/1535-7163.MCT-09-0150 DO - 10.1158/1535-7163.MCT-09-0150 ID - Hu2009 ER - TY - JOUR AU - Teicher, B. A. AU - Lazo, J. S. AU - Sartorelli, A. C. PY - 1981 DA - 1981// TI - Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells JO - Cancer Res VL - 41 ID - Teicher1981 ER - TY - JOUR AU - Hudson, C. C. AU - Liu, M. AU - Chiang, G. G. AU - Otterness, D. M. AU - Loomis, D. C. AU - Kaper, F. AU - Giaccia, A. J. AU - Abraham, R. T. PY - 2002 DA - 2002// TI - Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin JO - Mol Cell Biol VL - 22 UR - https://doi.org/10.1128/MCB.22.20.7004-7014.2002 DO - 10.1128/MCB.22.20.7004-7014.2002 ID - Hudson2002 ER - TY - JOUR AU - Mayerhofer, M. AU - Valent, P. AU - Sperr, W. R. AU - Griffin, J. D. AU - Sillaber, C. PY - 2002 DA - 2002// TI - BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin JO - Blood VL - 100 UR - https://doi.org/10.1182/blood-2002-01-0109 DO - 10.1182/blood-2002-01-0109 ID - Mayerhofer2002 ER - TY - JOUR AU - Pencreach, E. AU - Guerin, E. AU - Nicolet, C. AU - Lelong-Rebel, I. AU - Voegeli, A. C. AU - Oudet, P. AU - Larsen, A. K. AU - Gaub, M. P. AU - Guenot, D. PY - 2009 DA - 2009// TI - Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis JO - Clin Cancer Res VL - 15 UR - https://doi.org/10.1158/1078-0432.CCR-08-0889 DO - 10.1158/1078-0432.CCR-08-0889 ID - Pencreach2009 ER - TY - JOUR AU - Liu, L. AU - Cao, Y. AU - Chen, C. AU - Zhang, X. AU - McNabola, A. AU - Wilkie, D. AU - Wilhelm, S. AU - Lynch, M. AU - Carter, C. PY - 2006 DA - 2006// TI - Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5 JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-06-1377 DO - 10.1158/0008-5472.CAN-06-1377 ID - Liu2006 ER - TY - JOUR AU - D’Amato, R. J. AU - Loughnan, M. S. AU - Flynn, E. AU - Folkman, J. PY - 1994 DA - 1994// TI - Thalidomide is an inhibitor of angiogenesis JO - Proc Natl Acad Sci USA VL - 91 UR - https://doi.org/10.1073/pnas.91.9.4082 DO - 10.1073/pnas.91.9.4082 ID - D’Amato1994 ER - TY - JOUR AU - Bauer, K. S. AU - Dixon, S. C. AU - Figg, W. D. PY - 1998 DA - 1998// TI - Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species-dependent JO - Biochem Pharmacol VL - 55 UR - https://doi.org/10.1016/S0006-2952(98)00046-X DO - 10.1016/S0006-2952(98)00046-X ID - Bauer1998 ER - TY - JOUR AU - Brown, J. M. PY - 1999 DA - 1999// TI - The hypoxic cell: a target for selective cancer therapy–eighteenth Bruce F Cain Memorial Award lecture JO - Cancer Res VL - 59 ID - Brown1999 ER - TY - JOUR AU - Marcu, L. AU - Olver, I. PY - 2006 DA - 2006// TI - Tirapazamine: from bench to clinical trials JO - Curr Clin Pharmacol VL - 1 UR - https://doi.org/10.2174/157488406775268192 DO - 10.2174/157488406775268192 ID - Marcu2006 ER - TY - JOUR AU - Reddy, S. B. AU - Williamson, S. K. PY - 2009 DA - 2009// TI - Tirapazamine: a novel agent targeting hypoxic tumor cells JO - Expert Opin Investig Drugs VL - 18 UR - https://doi.org/10.1517/13543780802567250 DO - 10.1517/13543780802567250 ID - Reddy2009 ER - TY - JOUR AU - Rapisarda, A. AU - Uranchimeg, B. AU - Scudiero, D. A. AU - Selby, M. AU - Sausville, E. A. AU - Shoemaker, R. H. AU - Melillo, G. PY - 2002 DA - 2002// TI - Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway JO - Cancer Res VL - 62 ID - Rapisarda2002 ER - TY - JOUR AU - Kummar, S. AU - Raffeld, M. AU - Juwara, L. AU - Horneffer, Y. AU - Strassberger, A. AU - Allen, D. AU - Steinberg, S. M. AU - Rapisarda, A. AU - Spencer, S. D. AU - Figg, W. D. AU - Chen, X. AU - Turkbey, I. B. AU - Choyke, P. AU - Murgo, A. J. AU - Doroshow, J. H. AU - Melillo, G. PY - 2011 DA - 2011// TI - Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1alpha in advanced solid tumors JO - Clin Cancer Res VL - 17 UR - https://doi.org/10.1158/1078-0432.CCR-11-0682 DO - 10.1158/1078-0432.CCR-11-0682 ID - Kummar2011 ER - TY - JOUR AU - Liu, L. AU - Ning, X. AU - Sun, L. AU - Zhang, H. AU - Shi, Y. AU - Guo, C. AU - Han, S. AU - Liu, J. AU - Sun, S. AU - Han, Z. AU - Wu, K. AU - Fan, D. PY - 2008 DA - 2008// TI - Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer JO - Cancer Sci VL - 99 ID - Liu2008 ER - TY - JOUR AU - Lindhagen, E. AU - Nygren, P. AU - Larsson, R. PY - 2008 DA - 2008// TI - The fluorometric microculture cytotoxicity assay JO - Nat Protoc VL - 3 UR - https://doi.org/10.1038/nprot.2008.114 DO - 10.1038/nprot.2008.114 ID - Lindhagen2008 ER - TY - JOUR AU - Larsson, R. AU - Kristensen, J. AU - Sandberg, C. AU - Nygren, P. PY - 1992 DA - 1992// TI - Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA) JO - Int J Cancer VL - 50 UR - https://doi.org/10.1002/ijc.2910500204 DO - 10.1002/ijc.2910500204 ID - Larsson1992 ER - TY - JOUR AU - Lamb, J. AU - Crawford, E. D. AU - Peck, D. AU - Modell, J. W. AU - Blat, I. C. AU - Wrobel, M. J. AU - Lerner, J. AU - Brunet, J. P. AU - Subramanian, A. AU - Ross, K. N. AU - Reich, M. AU - Hieronymus, H. AU - Wei, G. AU - Armstrong, S. A. AU - Haggarty, S. J. AU - Clemons, P. A. AU - Wei, R. AU - Carr, S. A. AU - Lander, E. S. AU - Golub, T. R. PY - 2006 DA - 2006// TI - The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease JO - Science VL - 313 UR - https://doi.org/10.1126/science.1132939 DO - 10.1126/science.1132939 ID - Lamb2006 ER - TY - JOUR AU - Subramanian, A. AU - Tamayo, P. AU - Mootha, V. K. AU - Mukherjee, S. AU - Ebert, B. L. AU - Gillette, M. A. AU - Paulovich, A. AU - Pomeroy, S. L. AU - Golub, T. R. AU - Lander, E. S. AU - Mesirov, J. P. PY - 2005 DA - 2005// TI - Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles JO - Proc Natl Acad Sci USA VL - 102 UR - https://doi.org/10.1073/pnas.0506580102 DO - 10.1073/pnas.0506580102 ID - Subramanian2005 ER - TY - JOUR AU - da Huang, W. AU - Sherman, B. T. AU - Lempicki, R. A. PY - 2009 DA - 2009// TI - Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources JO - Nat Protoc VL - 4 UR - https://doi.org/10.1038/nprot.2008.211 DO - 10.1038/nprot.2008.211 ID - da Huang2009 ER - TY - JOUR AU - Elvidge, G. P. AU - Glenny, L. AU - Appelhoff, R. J. AU - Ratcliffe, P. J. AU - Ragoussis, J. AU - Gleadle, J. M. PY - 2006 DA - 2006// TI - Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M511408200 DO - 10.1074/jbc.M511408200 ID - Elvidge2006 ER - TY - JOUR AU - Vaupel, P. AU - Thews, O. AU - Hoeckel, M. PY - 2001 DA - 2001// TI - Treatment resistance of solid tumors: role of hypoxia and anemia JO - Med Oncol VL - 18 UR - https://doi.org/10.1385/MO:18:4:243 DO - 10.1385/MO:18:4:243 ID - Vaupel2001 ER - TY - JOUR AU - Rohwer, N. AU - Cramer, T. PY - 2011 DA - 2011// TI - Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways JO - Drug Resist Updat VL - 14 UR - https://doi.org/10.1016/j.drup.2011.03.001 DO - 10.1016/j.drup.2011.03.001 ID - Rohwer2011 ER - TY - JOUR AU - Schwartz, H. S. PY - 1962 DA - 1962// TI - Pharmacology of mitomycin C. III. In vitro metabolism by rat liver JO - J Pharmacol Exp Ther VL - 136 ID - Schwartz1962 ER - TY - JOUR AU - Iwai, A. AU - Fujii, Y. AU - Kawakami, S. AU - Takazawa, R. AU - Kageyama, Y. AU - Yoshida, M. A. AU - Kihara, K. PY - 2004 DA - 2004// TI - Down-regulation of vascular endothelial growth factor in renal cell carcinoma cells by glucocorticoids JO - Mol Cell Endocrinol VL - 226 UR - https://doi.org/10.1016/j.mce.2004.07.013 DO - 10.1016/j.mce.2004.07.013 ID - Iwai2004 ER - TY - JOUR AU - Tochizawa, S. AU - Masumori, N. AU - Yanai, Y. AU - Ohmoto, Y. AU - Yabuuchi, Y. AU - Tsukamoto, T. PY - 2008 DA - 2008// TI - Antitumor effects of a combination of interferon-alpha and sorafenib on human renal carcinoma cell lines JO - Biomed Res VL - 29 UR - https://doi.org/10.2220/biomedres.29.271 DO - 10.2220/biomedres.29.271 ID - Tochizawa2008 ER - TY - JOUR AU - Lee, T. H. AU - Seng, S. AU - Sekine, M. AU - Hinton, C. AU - Fu, Y. AU - Avraham, H. K. AU - Avraham, S. PY - 2007 DA - 2007// TI - Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1 JO - PLoS Med VL - 4 UR - https://doi.org/10.1371/journal.pmed.0040186 DO - 10.1371/journal.pmed.0040186 ID - Lee2007 ER - TY - JOUR AU - Lee, J. H. AU - Shim, J. W. AU - Choi, Y. J. AU - Heo, K. AU - Yang, K. PY - 2013 DA - 2013// TI - The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1alpha expression JO - Oncol Rep VL - 29 ID - Lee2013 ER - TY - JOUR AU - Spannuth, W. A. AU - Nick, A. M. AU - Jennings, N. B. AU - Armaiz-Pena, G. N. AU - Mangala, L. S. AU - Danes, C. G. AU - Lin, Y. G. AU - Merritt, W. M. AU - Thaker, P. H. AU - Kamat, A. A. AU - Han, L. Y. AU - Tonra, J. R. AU - Coleman, R. L. AU - Ellis, L. M. AU - Sood, A. K. PY - 2009 DA - 2009// TI - Functional significance of VEGFR-2 on ovarian cancer cells JO - Int J Cancer VL - 124 UR - https://doi.org/10.1002/ijc.24028 DO - 10.1002/ijc.24028 ID - Spannuth2009 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/13/331/prepub UR - http://www.biomedcentral.com/1471-2407/13/331/prepub ID - ref81 ER -