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Table 6 APOA1 rs670 A/A carriage predicts poor post-surgery survival in breast cancer after adjustments for lymph node and ER/PR status

From: The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: a 10-year follow-up study

 

Unadjusted

Adjusted (n=186)

HR (95% CI)

P value

HR (95% CI)

P value

Recurrence

    

Lymph node positivitya

2.86 (1.65-4.96)

<0.001

2.20 (1.18-4.10)

0.013

ER/PR negativityb

1.90 (1.08-3.37)

0.027

1.53 (0.85-2.77)

0.156

Age

1.01 (0.98-1.04)

0.479

-

-

BMIc

1.00 (0.93-1.08)

1.000

-

-

Combined therapyd

2.64 (1.46-4.78)

0.001

2.03 (1.01-4.08)

0.046

APOA1 rs670 A/Ae

4.02 (2.22-9.96)

0.001

3.02 (1.25-7.29)

0.014

Mortality

    

Lymph node positivitya

6.01 (2.62-13.80)

<0.001

2.09 (1.01-4.29)

0.046

ER/PR negativityb

2.30 (1.13-4.70)

0.022

4.54 (1.88-10.94)

0.001

Age

1.03 (0.99-1.06)

0.127

-

-

BMIc

1.00 (0.91-1.10)

0.942

-

-

Combined therapyd

3.45 (1.50-7.98)

0.004

2.11 (0.84-5.31)

0.114

APOA1 rs670 A/Ae

6.30 (2.47-16.08)

<0.001

4.47 (1.56-12.79)

0.005

  1. NOTE: P values were results of Cox proportional hazard regression analysis. Bold type indicates p<0.050.
  2. a, compared with negative lymph node involvement, n=211.
  3. b, compared with ER/PR positive, n=196.
  4. c, n=185.
  5. d, compared with TAM only.
  6. e, compared with APOA1 rs670 G/G.
  7. Abbreviations: BMI Body mass index, ER estrogen receptor, HR Hazard ratio, PR progesterone receptor.