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Table 6 APOA1 rs670 A/A carriage predicts poor post-surgery survival in breast cancer after adjustments for lymph node and ER/PR status

From: The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: a 10-year follow-up study

  Unadjusted Adjusted (n=186)
HR (95% CI) P value HR (95% CI) P value
Recurrence     
Lymph node positivitya 2.86 (1.65-4.96) <0.001 2.20 (1.18-4.10) 0.013
ER/PR negativityb 1.90 (1.08-3.37) 0.027 1.53 (0.85-2.77) 0.156
Age 1.01 (0.98-1.04) 0.479 - -
BMIc 1.00 (0.93-1.08) 1.000 - -
Combined therapyd 2.64 (1.46-4.78) 0.001 2.03 (1.01-4.08) 0.046
APOA1 rs670 A/Ae 4.02 (2.22-9.96) 0.001 3.02 (1.25-7.29) 0.014
Mortality     
Lymph node positivitya 6.01 (2.62-13.80) <0.001 2.09 (1.01-4.29) 0.046
ER/PR negativityb 2.30 (1.13-4.70) 0.022 4.54 (1.88-10.94) 0.001
Age 1.03 (0.99-1.06) 0.127 - -
BMIc 1.00 (0.91-1.10) 0.942 - -
Combined therapyd 3.45 (1.50-7.98) 0.004 2.11 (0.84-5.31) 0.114
APOA1 rs670 A/Ae 6.30 (2.47-16.08) <0.001 4.47 (1.56-12.79) 0.005
  1. NOTE: P values were results of Cox proportional hazard regression analysis. Bold type indicates p<0.050.
  2. a, compared with negative lymph node involvement, n=211.
  3. b, compared with ER/PR positive, n=196.
  4. c, n=185.
  5. d, compared with TAM only.
  6. e, compared with APOA1 rs670 G/G.
  7. Abbreviations: BMI Body mass index, ER estrogen receptor, HR Hazard ratio, PR progesterone receptor.