The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: a 10-year follow-up study

Table 3 APOA1 rs670 A allele carrying patients had increased odds of lymph node involvement and hormone receptor expression negativity at baseline

	Multinominal logistic regression (using APOA1 rs670 G/G as reference)
	APOA1 rs670 G/A			APOA1 rs670 A/A
	OR	95% Cl	P value	OR	95% Cl	P value
Tumor type (using infiltrating ductal carcinoma as reference)
Ductal carcinoma in situ	0.38	0.12-1.15	0.086	0.64	0.13-3.11	0.575
Others	0.6	0.16-2.32	0.461	1.27	0.23-6.99	0.784
Unknown	0	0-0	N/A	0	0-0	N/A
Side (using right as reference)
Left	0.66	0.37-1.18	0.160	0.69	0.28-1.66	0.402
Bilateral	0.67	0.16-2.87	0.593	0.67	0.07-6.59	0.734
Tumor size (using <5cm as reference)
≥5cm	2.25	0.83-6.08	0.111	2.25	0.57-8.79	0.245
Unknown	0.59	0.28-1.26	0.173	0.67	0.21-2.21	0.515
Lymph node involvement (using positive as reference)
Negative	3.32	1.77-6.20	<0.001	2.58	1.05-6.32	0.039
Unknown	0.95	0.28-3.18	0.930	0	0-0	N/A
TMN staging (using stages 0–2 as reference)
Stages >2	2.41	0.95-6.11	0.064	1.8	0.48-6.79	0.385
Unknown	0.71	0.34-1.49	0.364	0.47	0.13-1.76	0.263
ER/PR status (using positive as reference)
Negative	1.85	0.88-3.92	0.106	4.85	1.83-12.83	0.001
Unknown	0.79	0.34-1.85	0.592	0.35	0.04-2.87	0.326
Family history (using negative as reference)
Positive	0.63	0.14-2.88	0.548	0	0-0	N/A
Unknown	1	0.30-3.40	0.997	1.3	0.24-7.09	0.765

NOTE: Bold type indicates p<0.050.
Abbreviations: CI confidence interval, ER estrogen receptor, PR progesterone receptor, OR odds ratio.

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