Table 1 Analysis of genotype data from melanoma cases and controls for polymorphisms on chromosome 9p21 locus

rs751173

TT

211 (27.2)

358 (31.1)

Reference

TC

384 (49.6)

573 (49.7)

1.18

0.94 –1.47

CC

179 (23.1)

221 (19.2)

1.43

1.09-1.87

0.04

TC+CC

563 (72.7)

794 (68.9)

1.25

1.01-1.54

0.04

T allele

806 (52.1)

1286 (56)

Reference

C allele

742 (47.9)

1015 (44.1)

1.19

1.04–1.37

0.01

MAF

0.48

0.44

rs4636294

GG

169 (21.9)

280 (24.3)

Reference

AG

375 (48.5)

605 (52.5)

1.07

0.84–1.36

AA

229 (29.6)

268 (23.2)

1.41

1.08–1.85

0.02

AG+AA

604 (78.1)

873 (75.7)

1.17

0.93–1.47

0.16

G allele

713 (46.1)

1165 (50.5)

Reference

A allele

833 (53.9)

1141 (49.5)

1.19

1.04–1.36

0.01

MAF

0.54

0.50

rs2218220

TT

167 (21.6)

281 (24.4)

Reference

CT

379 (49)

607 (52.7)

1.09

0.86–1.39

CC

228 (29.5)

264 (22.9)

1.45

1.11–1.91

0.01

TC+CC

607 (78.4)

871 (75.6)

1.20

0.96–1.51

0.12

T allele

713 (46.1)

1169 (50.7)

Reference

C allele

835 (53.9)

1135 (49.3)

1.21

1.05–1.38

0.007

MAF

0.54

0.49

rs1335510

TT

323 (41.8)

406 (35.4)

Reference

TG

352 (45.6)

568 (49.5)

0.79

0.64–0.97

GG

97 (12.5)

173 (15.1)

0.67

0.49–0.91

0.01

TG+GG

449 (58.2)

741 (64.6)

0.76

0.63–0.93

0.007

T allele

998 (64.6)

1380 (60.2)

Reference

G allele

546 (35.4)

914 (39.8)

0.81

0.71–0.94

0.004

MAF

0.35

0.40

rs1341866

TT

316 (40.8)

398 (34.6)

Reference

TC

361 (46.6)

576 (50)

0.81

0.66–0.99

CC

97 (12.5)

177 (15.4)

0.66

0.49–0.90

0.02

TC+CC

458 (59.2)

753 (65.4)

0.77

0.63–0.94

0.01

T allele

993 (64.2)

1372 (59.6)

Reference

C allele

555 (35.9)

930 (40.4)

0.82

0.71–0.94

0.004

MAF

0.36

0.40

rs935053

AA

172 (22.3)

293 (25.4)

Reference

AG

373 (48.3)

601 (52)

1.10

0.87–1.40

GG

228 (29.5)

259 (22.5)

1.48

1.13–1.94

0.009

AG+GG

601 (78 )

860 (74.6)

1.22

0.97–1.53

0.08

A allele

717 (46.4)

1187 (51.5)

Reference

G allele

829 (53.6)

1119 (48.5)

1.22

1.06–1.39

0.004

MAF

0.54

0.49

rs10757257

GG

320 (41.3)

407 (35.4)

Reference

GA

360 (46.5)

567 (49.3)

0.83

0.68–1.02

AA

94 (12.1)

177 (15.4)

0.65

0.48–0.88

0.02

GA+AA

454 (58.7)

744 (64.6)

0.79

0.65–0.96

0.02

G allele

1000 (64.6)

1381 (60)

Reference

A allele

548 (35.4)

921 (40)

0.81

0.71–0.94

0.004

MAF

0.35

0.40

rs7023329

AA

230 (29.7)

290 (25.2)

Reference

AG

377 (48.7)

576 (50)

0.84

0.67–1.06

GG

167 (21.6)

287 (24.9)

0.74

0.56–0.96

0.08

AG+GG

544 (70.3)

863 (74.9)

0.81

0.65–1.00

0.05

A allele

837 (54.1)

1156 (50.1)

Reference

G allele

711 (45.9)

1150 (49.9)

0.86

0.75–0.98

0.02

MAF

0.46

0.50

rs10811629

AA

313 (40.4)

395 (34.4)

Reference

AG

362 (46.8)

579 (50.4)

0.83

0.68–1.03

GG

99 (12.8)

174 (15.2)

0.70

0.52–0.95

0.05

AG+GG

461 (59.6)

753 (65.6)

0.80

0.66–0.98

0.03

A allele

988 (63.8)

1369 (59.6)

Reference

G allele

560 (36.2)

927 (40.4)

0.84

0.73–0.97

0.02

MAF

0.36

0.40

rs1011970

GG

549 (71.3)

850 (74.1)

Reference

GT

190 (24.7)

277 (24.2)

1.03

0.82–1.29

TT

31 (4)

19 (1.7)

2.24

1.22–4.13

0.04

GT+TT

221 (28.7)

296 (25.8)

1.11

0.89–1.38

0.35

G allele

1288 (83.6)

1977 (86.3)

Reference

T allele

252 (16.4)

315 (13.7)

1.18

0.97- 1.42

0.10

MAF

0.17

0.14

CDKN2A tagging polymorphysms

SNP

Cases (%)

Controls (%)

OR

95% CI

P value

rs3731257

GG

398 (52)

595 (51.8)

Reference

GA

302 (39.5)

455 (39.6)

0.94

0.77–1.15

AA

65 (8.5)

98 (8.5)

0.89

0.63–1.27

0.73

GA+AA

367 (48)

553 (48.2)

0.93

0.77–1.13

0.46

G allele

1098 (71.8)

1645 (71.7)

Reference

A allele

432 (28.2)

651 (28.4)

0.94

0.81–1.09

0.43

MAF

0.28

0.28

rs11515

GG

538 (69.7)

796 (69.6)

Reference

GC

214 (27.7)

316 (27.7)

0.96

0.78–1.19

CC

20 (2.6)

31 (2.7)

0.91

0.50–1.67

0.91

GC +CC

234 (30.3)

347 (30.4)

0.96

0.78–1.18

0.68

G allele

1290 (83.6)

1908 (83.5)

Reference

C allele

254 (16.5)

378 (16.5)

0.96

0.80–1.15

0.66

MAF

0.17

0.17

rs3088440

CC

660 (85.4)

1020 (90)

Reference

CT

108 (14)

108 (9.5)

1.52

1.13–2.05

TT

5 (0.7)

5 (0.4)

1.50

0.40–5.58

0.02

CT+TT

113 (14.6)

113 (10)

1.52

1.14–2.04

0.005

C allele

1428 (92.4)

2148 (94.8)

Reference

T allele

118 (7.6)

118 (5.2)

1.48

1.12–1.96

0.005

MAF

0.08

0.05

rs2518719

AA

541 (70.8)

808 (70.4)

Reference

AG

206 (27)

320 (27.9)

1.04

0.84–1.30

GG

17 (2.2)

19 (1.7)

1.58

0.79–3.19

0.42

AG+GG

223 (29.2)

339 (29.6)

1.07

0.87–1.33

0.51

A allele

1288(84.3)

1936 (84.4)

Reference

G allele

240 (15.7)

358 (15.6)

1.09

0.91–1.31

0.36

MAF

0.16

0.16

rs2811708

GG

369 (46.8)

563 (49.1)

Reference

GT

332 (43)

475 (41.5)

1.09

0.89–1.33

TT

71 (9.2)

108 (9.4)

1.05

0.74–1.48

0.70

GT + TT

403 (52.2)

583 (50.9)

1.08

0.89–1.31

0.42

G allele

1070 (69.3)

1601 (69.9)

Reference

T allele

474 (30.7)

691 (30.2)

1.05

0.91–1.22

0.52

MAF

0.31

0.30

rs3731239

AA

356 (46.8)

494 (43)

Reference

AG

318 (41.8)

536 (46.6)

0.84

0.68–1.03

GG

86 (11.3)

120 (10.4)

1.08

0.78–1.50

0.13

AG+GG

404 (53.2)

656 (57)

0.88

0.73–1.07

0.20

A allele

1030 (67.8)

1524 (66.3)

Reference

G allele

490 (32.2)

776 (33.7)

0.97

0.84–1.12

0.65

MAF

0.33

0.34

rs2811710

CC

286 (37)

450 (39.3)

Reference

CT

355 (45.9)

542 (47.3)

1.03

0.82–1.27

TT

132 (17.1)

154 (13.4)

1.40

1.05–1.87

0.06

CT+TT

487 (63)

696 (60.7)

1.10

0.91–1.35

0.30

C allele

927 (60)

1442 (62.9)

Reference

T allele

619 (40)

850 (37.1)

1.15

1.00–1.32

0.05

MAF

0.40

0.37

rs3218020

GG

254 (32.8)

381 (33.2)

Reference

GA

375 (48.5)

560 (48.8)

0.97

0.78–1.20

AA

145 (18.7)

206 (17.9)

0.96

0.73–1.27

0.95

GA+AA

520 (67.2)

766 (66.8)

0.97

0.79–1.18

0.74

G allele

883 (57)

1322 (57.6)

Reference

A allele

665 (43)

972 (42.4)

0.98

0.85–1.12

0.76

MAF

0.43

0.42

rs3218009

CC

650 (84)

965 (83.8)

Reference

CG

118 (15.3)

180 (15.6)

1.01

0.77–1.31

GG

6 (0.8)

6 (0.5)

1.96

0.61–6.29

0.52

CG+GG

124 (16)

186 (16.2)

1.04

0.80–1.34

0.79

C allele

1418 (91.6)

2110 (91.7)

Reference

G allele

130 (8.4)

192 (8.3)

1.06

0.83–1.35

0.63

MAF

0.08

0.08

rs3217992

CC

229 (29.9)

341 (29.7)

Reference

CT

380 (49.7)

565 (49.2)

0.95

0.76–1.19

TT

156 (20.4)

243 (21.2)

0.89

0.68–1.17

0.72

CT+TT

536 (70.1)

808 (70.3)

0.94

0.76–1.15

0.53

C allele

838 (54.8)

1247 (54.3)

Reference

T allele

692 (45.2)

1051 (45.7)

0.95

0.83–1.08

0.42

MAF

0.45

0.46

rs1063192

AA

316 (40.9)

445 (38.8)

Reference

AG

365 (47.3)

537 (46.9)

0.99

0.80–1.22

GG

91 (11.8)

164 (14.3)

0.89

0.65–1.20

0.72

AG+GG

456 (59.1)

701 (61.2)

0.97

0.79–1.17

0.72

A allele

997 (64.6)

1427 (62.3)

Reference

G allele

547 (35.4)

865 (37.7)

0.95

0.83–1.10

0.51

MAF

0.35

0.38

rs573687

GG

380 (49.3)

532 (46.4)

Reference

GA

329 (42.7)

501 (43.7)

0.95

0.78–1.17

AA

62 (8)

114 (9.9)

0.86

0.61–1.22

0.68

GA+AA

391 (50.7)

615 (53.6)

0.94

0.77–1.14

0.50

G allele

1089 (70.6)

1565 (68.2)

Reference

A allele

453 (29.4)

729 (31.8)

0.94

0.81–1.09

0.40

MAF

0.29

0.32

rs13298881

TT

565 (73.8)

862 (75.2)

Reference

TC

183 (23.9)

262 (22.8)

1.14

0.91–1.43

CC

18 (2.4)

23 (2)

1.26

0.65–2.45

0.46

TC+CC

201 (26.2)

285 (24.9)

1.15

0.92–1.43

0.22

T allele

1313 (85.7)

1986 (86.6)

Reference

C allele

219 (14.3)

308 (13.4)

1.14

0.93–1.38

0.21

MAF

0.14

0.13

rs545226

AA

207 (26.8)

300 (26.1)

Reference

AG

378 (48.9)

577 (50.3)

0.88

0.70–1.11

GG

188 (24.3)

271 (23.6)

0.93

0.71–1.22

0.55

AG+GG

566 (73.2)

848 (73.9)

0.90

0.72–1.11

0.32

A allele

792 (51.2)

1177 (51.3)

Reference

G allele

754 (48.8)

1119 (48.7)

0.96

0.84–1.10

0.57

MAF

0.49

0.49

rs10811640

GG

184 (24.1)

298 (26.1)

Reference

GT

371 (48.5)

565 (49.4)

1.02

0.81–1.29

TT

210 (27.5)

280 (24.5)

1.12

0.86–1.46

0.68

GT+TT

581 (76)

845 (73.9)

1.05

0.84–1.32

0.65

G allele

739 (48.3)

1161 (50.8)

Reference

T allele

791 (51.7)

1125 (49.2)

1.06

0.92–1.21

0.42

MAF

0.52

0.49