Skip to main content

Table 2 Percentages of lymphocyte populations and their subset composition in pleural fluid assessed in healthy subjects and in patients. Results given as median (interquartile range)

From: Defect in recruiting effector memory CD8+T-cells in malignant pleural effusions compared to normal pleural fluid

  METS BPLAE MPM Healthy subjects
Lymphocyte populations a
  Total CD3+ T-cells 80.5 (76–87.5) 85.2 (81–90.1) 77 (69–84) 85 (80–88)
  CD4+ T-cells 63.2 (53.8-72) 63.5 (52.5-72) 54.2 (44–62.5) 30.0 (21–32)
  CD8+ T-cells 19 (15–25) 22 (16.4-29) 25 (19.2-33.5) 53 (45–59)
  CD4+/CD8+ ratio 3.8 (2.6-4.8) 3.2 (2.2-4.5) 2.2 (1.5-2.9) 0.59 (0.48-0.67)
  Treg (CD4low+CD25bright+)b 4.4 (3–5.9) 4.4 (2.4-5.3) 3.1 2.2 (1.6-3.7)
  NK cells (CD3CD56+) 3.5 (2.2-7.5) 2.8 (2–4) 10 (3.4-12.5) 16.0 (12.4-24.1)
  → % of CD16 + NK cells 30 (20–59) 18 (1–35) 26 (14–54) 6% (3–8)
CD4 + T cell subsets b
  Naïve 22.7 (14.7-29) 25.7 (14.3-37) 11.2 (3.8-27) 1.6 (1–2.4)
  TCM 47.4 (30–62) 53.5 (42.9-60) 40.5 (27.5-51) 13.1 (9.8-19.6)
  TEM 21 (11.4-38.2) 18.6 (10.2-22) 19.2 (9.3-32) 85.1 (77.2-88.9)
  TTD 0.6 (0.3-1.4) 1.3 (0.5-1.7) 0.8 (0.3-1.6) 0.7 (0.3-1)
CD8 + T cell subsets b
  Naïve 15.2 (7.1-37.3) 26 (22–43.4) 11.2 (3.9-29.6) 1.4 (0.9-2.1)
  TCM 22.1 (12–34.7) 27.4 (17.8-44) 11.6 (7.2-28.3) 2.3 (1.6-4.7)
  TEM 19.7 (4.3-45.3) 16.1 (10.7-36) 18.6 (5.6-49.2) 84.7 (83.1-87)
  TTD 12.7 (5.6-22.3) 13.7 (8–22.9) 7.4 (2.4-20.7) 9.5 (8.5-12.2)
  1. aAs a percentage of the total lymphocytes (defined as CD45bright, low side scatter).
  2. bAs a percentage of the total CD4+ or CD8+ T-cell population. The total may add up to slightly less or more than 100% because medians of individual subsets are given. the interquartile range for the MPM group could not be safely calculated due to the low number of cases; T CM central-memory cells, T EM effector memory cells, T TD terminally-differentiated effector memory.