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Figure 1 | BMC Cancer

Figure 1

From: Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous cell carcinoma experimental models

Figure 1

Anti-lymphatic effects of rapamycin in the orthotopic OSCC tongue tumor model. A, Extraction of cervical lymph nodes. B, Mouse tongue with OSC-19 tumors formed after tumor cells injection. C-D, Effects of rapamycin on the number of LYVE + lymphatic vessels invaded by tumor cells in mouse lingual tissues. E-G, Extent of lymph node metastasis. E, Lymph node (H&E stain) with extensive tumor involvement (control mouse). F, Lymph node (H&E stain), no tumor metastasis (rapamycin-treated mouse). G, Lymph node (H&E stain) with subcapsular metastasis indicated by arrows (rapamycin-treated mouse). H-I, Detection of lymph node metastasis using cytokeratin staining.

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BMC Cancer

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