Treatment pattern | Treatment days | Total spread scored | Chromosome no. | Aneuploidy | Premature sister | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  | 37 | 38 | 39 | 40 | 41 | 42 | >60 | % (Mean) | Chromatid separation % |
Untreated | 0 | 110 | Â | Â | Â | 110 | Â | Â | Â | 0 | 0 |
 |  | 104 |  |  |  | 104 |  |  |  | 0 | 0 |
RAN | 120 | 105 | Â | 1 | 1 | 103 | Â | Â | Â | 1.9 | 17.5 |
 |  | 120 | 2 | 1 | 2 | 115 |  |  |  | 4.1 | 18.7 |
 |  | 105 | 1 | 2 |  | 102 |  |  |  | 2.8 (2.9) | 18.3 (18.2) |
RAN + lime |  | 100 | 2 | 2 | 1 | 95 |  |  |  | 5.0 | 31.7 |
 |  | 105 | 2 | 2 | 3 | 98 |  |  |  | 6.6 | 28.6 |
 |  | 110 | 3 | 2 | 1 | 103 |  | 1 |  | 6.4 (6.0) | 28.3 (29.5) |
 |  |  |  |  |  |  |  |  |  |  | p = 0.015a |
RAN | 180 | 101 | 1 | 2 | 1 | 97 | Â | Â | Â | 3.9 | 18.0 |
 |  | 124 | 2 | 2 | 1 | 119 |  |  |  | 4.0 | 17.7 |
 |  | 114 | 3 | 2 | 1 | 108 |  |  |  | 5.3 (4.4) | 19.4 (18.4) |
RAN + lime |  | 112 | 3 | 3 | 3 | 103 |  |  |  | 8.0 | 32.6 |
 |  | 105 | 2 | 2 | 1 | 98 |  | 1 | 1 | 6.6 | 34.9 |
 |  | 110 | 4 | 2 |  | 101 |  | 2 | 1 | 8.2 (7.6) | 35.6 (34.4) |
 |  |  |  |  |  |  |  |  |  |  | p = 0.002a |
RAN + lime | 220 | 232 | 6 | 9 | 12 | 194 | 7 | 2 | 2 | 16.4 | 8.2 |
(with advanced tumor) | 256 | 234 | 5 | 4 | 7 | 208 | 5 | 2 | 3 | 11.1 (13.8) | 7.1 (7.6) |