Figure 4

Upper panel- Expression of mitotic checkpoint genes in mouse bone marrow (BM), esophagus and stomach cells after exposure with RAN extract with or without lime for 120, 180 and 260 days. Lower panel- Quantitative densitometric analysis of the expression profile of mitotic checkpoint genes mRNA level in esophagus and stomach cells after 260 days of exposure was shown. The values are the mean ± SEM of three independent experiments. The values are normalized to respective GAPDH values. * p < 0.05; ** p < 0.01; *** p < 0.001. Significantly different compared with negative/positive control (as determined by paired t-test).