BMC Cancer

Table 4 Methylation in imprinted genes by tumor location and histology

From: DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors

	Females				Males
Average Methylation¹	YST	Germinoma	Teratoma		YST	Teratoma
			Ovarian	Extragonadal
	N² (%)	N² (%)	N² (%)	N² (%)	N² (%)	N² (%)
	Paternal Allele Methylated
*H19* CTCF3
< 33%	2 (25)	4 (67)	9 (90)	1 (12)	2 (50)	1 (25)
33-66%	6 (75)	2 (33)	1 (10)	7 (88)	1 (25)	3 (75)
> 66%	0	0	0	0	1 (25)	0
				0.003
*H19* CTCF6
< 33%	4 (50)	5 (83)	9 (90)	2 (29)	2 (50)	3 (75)
33-66%	4 (50)	1 (17)	1 (10)	5 (71)	2 (50)	1 (25)
> 66%	0	0	0	0	0	0
				0.04
*IGF2*
< 33%	2 (29)	4 (67)	8 (80)	1 (12)	0	0
33-66%	5 (71)	2 (33)	2 (20)	7 (88)	4 (100)	4 (100)
> 66%	0	0	0	0	0	0
				0.02
	Maternal Allele Methylated
*KvDMR*
< 33%	2 (25)	4 (67)	0	3 (37)	3 (75)	1 (25)
33-66%	6 (75)	2 (33)	2 (20)	5 (63)	0	3 (75)
> 66%	0	0	8 (80)	0	1 (25)	0
				<0.0001
*PEG3*
< 33%	0	6 100)	0	1 (12)	0	0
33-66%	6 (75)	0	1 (10)	7 (88)	1 (33)	4 (100)
> 66%	2 (25)	0	9 (90)	0	2 (67)	0
				<0.0001
*SNRPN*
< 33%	3 (38)	6 (100)	1 (10)	2 (25)	4 (100)	0
33-66%	5 (62)	0	0	6 (75)	0	4 (100)
> 66%	0	0	9 (90)	0	0	0
				<0.0001

¹Categories represent three methylation states based on the average percent methylation across all CpG loci analyzed in the DMR: <33% (hypomethylation), 33-66% (median methylation), and >66% methylation (hypermethylation).
² N’s do not sum to total due to missing data.

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ISSN: 1471-2407

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