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Table 2 Top 23 genes with differential methylation in YST

From: DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors

CpG Locus Effect sizea q-value Δ beta YST1b Δ beta YST2b
HLA . F _ E402 _ F 3.69 <2.2E-16 0.86 0.81
WT1 _ E32 _ F 3.41 <2.2E-16 0.86 0.83
RASSF1 _ E116 _ F 3.16 <2.2E-16 0.87 0.79
CYP1B1 _ E83 _ R 3.13 <2.2E-16 0.74 0.54
CCNA1_E7_F 3.13 <2.2E-16 0.67 0.78
SLC22A3_E122_R 3.12 <2.2E-16 0.82 0.74
SCGB3A1_E55_R 3.05 <2.2E-16 0.80 0.77
HOXA9_E252_R 2.99 <2.2E-16 0.78 0.76
TFAP2C_E260_F 2.98 <2.2E-16 0.81 0.71
FGF3_P171_R 2.96 <2.2E-16 0.78 0.75
PDGFRB_P343_F 2.95 <2.2E-16 0.67 0.55
NPY_P295_F 2.92 <2.2E-16 0.81 0.75
ASCL2_P360_F 2.90 <2.2E-16 0.82 0.70
LRRC32_P865_R 2.90 <2.2E-16 0.81 0.44
CDK10_E74_F 2.88 <2.2E-16 0.83 0.65
HFE_E273_R 2.87 <2.2E-16 0.80 0.75
SOX1_P294_F 2.86 <2.2E-16 0.79 0.70
TAL1_P594_F 2.83 <2.2E-16 0.78 0.73
RASGRF1_E16_F 2.80 <2.2E-16 0.64 0.73
WT1_P853_F 2.79 <2.2E-16 0.78 0.73
HLF_E192_F 2.77 <2.2E-16 0.80 0.75
GUCY2D_E419_R 2.75 <2.2E-16 0.83 0.06
HS3ST2_E145_R 2.75 <2.2E-16 0.84 0.79
  1. a Indicates the adjusted fold change in the β value in the YST compared with the other histologic subtypes of GCT.
  2. b Indicates the change in the β value in the tumor sample compared to the paired normal adjacent in the two YST with available normal tissue.