Figure 3

Correlation of methylation status and expression level for selected Wnt pathway genes. A. Log₂fold-change in expression of selected Wnt pathway genes in GER compared to YST plotted as a function of methylation level (expressed as the mean delta LOD). Of the 24 genes profiles, 12 exhibit higher expression and less methylation in YSTs (gray rectangle). B. Unsupervised clustering of Wnt pathway gene expression in pediatric gem cell tumors. The genes shown are differentially expressed in germinomas compared to yolk sac tumors (p ≤ 0.05 by two-tailed t-test). Red indicates high expression and green low expression.