TY - JOUR AU - Niimi, Rui AU - Matsumine, Akihiko AU - Iino, Takahiro AU - Nakazora, Shigeto AU - Nakamura, Tomoki AU - Uchida, Atsumasa AU - Sudo, Akihiro PY - 2013 DA - 2013/06/26 TI - Soluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors JO - BMC Cancer SP - 309 VL - 13 IS - 1 AB - Neural-cadherin (N-cadherin) is one of the most important molecules involved in tissue morphogenesis, wound healing, and the maintenance of tissue integrity. Recently, the cleavage of N-cadherin has become a focus of attention in the field of cancer biology. Cadherin and their ectodomain proteolytic shedding play important roles during cancer progression. The aims of this study are to investigate the serum soluble N-cadherin (sN-CAD) levels in patients with malignant bone and soft tissue tumors, and to evaluate the prognostic significance of the sN-CAD levels. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-13-309 DO - 10.1186/1471-2407-13-309 ID - Niimi2013 ER -