Figure 4From: Ultrasonic spectrum analysis for in vivo characterization of tumor microstructural changes in the evaluation of tumor response to chemotherapy using diagnostic ultrasound Histopathologic analysis of tumor cell nuclei density. (A) The graph displays the mean density of tumor cell nuclei in the control and treated tumors (* = p < .001). (B) and (C) Representative photomicrographs of hemotoxylin and eosin stained sections of the control (B) and treated (C) tumors. Staining revealed microstructural changes in the tumor treated with adriamycin, including a decreased density of cell nuclei, and cytoplasmic and nuclear vacuolation, and clumping of nuclear chromatin (original magnification, ×400).Back to article page