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Table 8 The antiproliferative effect of vitamin D analogs with 5-FU on human and mouse colon cancer cells

From: Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

Vitamin D compounds

Colon cancer cell line [%]

HT-29

LoVo

MC38/0

 

+ 5-FU

%H

 

+ 5-FU

%H

 

+ 5-FU

%H

-

8 ± 7

-

10 ± 5

-

9 ± 7

-

Calcitriol

32 ± 5

49ab ± 6

37

0

25a ± 11

10

5 ± 8

24 ± 2

14

PRI-2191

28 ± 4

46ab ± 5

34

0

14 ± 7

10

0

12 ± 4

9

PRI-2201

29 ± 5

48ab ± 6

35

0

14 ± 7

10

0

16 ± 7

9

PRI-2205

8 ± 3

24ab ± 8

16

9 ± 6

24 ± 6

18

13 ± 10

41ab ± 10

17

  1. [%] – proliferation inhibition.
  2. %H = 100-[(100-E for cytostatic) × (100-E for calcitriol analog) /100], where E was the percentage of proliferation inhibition.
  3. On HT-29 and LoVo cells 5-FU was used in concentrations of 0.1 μg/ml and on MC38/0 – 0.01 μg/ml. Vitamin analogs were used in concentrations of 100 nM.
  4. a P < 0.05 as compared to 5-FU; ab P < 0.05 as compared to calcitriol or vitamin D analog.
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BMC Cancer

ISSN: 1471-2407

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