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Table 8 The antiproliferative effect of vitamin D analogs with 5-FU on human and mouse colon cancer cells

From: Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

Vitamin D compounds Colon cancer cell line [%]
HT-29 LoVo MC38/0
  + 5-FU %H   + 5-FU %H   + 5-FU %H
- 8 ± 7 - 10 ± 5 - 9 ± 7 -
Calcitriol 32 ± 5 49ab ± 6 37 0 25a ± 11 10 5 ± 8 24 ± 2 14
PRI-2191 28 ± 4 46ab ± 5 34 0 14 ± 7 10 0 12 ± 4 9
PRI-2201 29 ± 5 48ab ± 6 35 0 14 ± 7 10 0 16 ± 7 9
PRI-2205 8 ± 3 24ab ± 8 16 9 ± 6 24 ± 6 18 13 ± 10 41ab ± 10 17
  1. [%] – proliferation inhibition.
  2. %H = 100-[(100-E for cytostatic) × (100-E for calcitriol analog) /100], where E was the percentage of proliferation inhibition.
  3. On HT-29 and LoVo cells 5-FU was used in concentrations of 0.1 μg/ml and on MC38/0 – 0.01 μg/ml. Vitamin analogs were used in concentrations of 100 nM.
  4. a P < 0.05 as compared to 5-FU; ab P < 0.05 as compared to calcitriol or vitamin D analog.