Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

BMC Cancer

Table 3 The effect of vitamin D analogs alone or in combination with 5-FU on tumor growth, life span and body weight of mice bearing subcutaneously MC38 colon cancer

Analog (AN)	5-FU	AN	TGI [%] on the 25th day of the experiment					ILS [%]					Maximal decrease
			TGI [%] on the 25th day of the experiment					ILS [%]					in body weight [%]
			5-FU	AN	5-FU + AN	%H TGI	Effect	5-FU	AN	5-FU + AN	%H ILS	Effect	5-FU	AN	5-FU + AN
PRI-2191	100 mg/kg	0.2 μg/kg	69	42	73	82	Subadditive	63	4	67	64	No effect	4	7	4
PRI-2205	100 mg/kg	20 μg/kg	69	-16	72	64	Synergism	63	0	83	62	Synergism	4	5	1

Vitamin D analog was administered subcutaneously, five times a week.
AN Analog of vitamin D, TGI Tumor growth inhibition, %H TGI Hypothetical tumor growth inhibition, ILS Increase in life span, %H ILS Hypothetical increase in life span, Number of mice: control - 9; PRI-2191 – 7, PRI-2205: 7, 5-FU: 5, 5-FU + PRI-2205: 6, 5-FU + PRI-2191 – 7.
Mice bearing s.c. MC38 colon cancer cells were i.v. injected with 5-FU at a dose of 100 mg/kg/day on days: 2 and 17 and/or vitamin D analogs: PRI-2191 at a dose of 0.2 μg/kg/day or PRI-2205 at a dose of 20 μg/kg/day. Both analogs were administrated s.c., five times a week from days: 9 to 25.

ISSN: 1471-2407