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Table 3 The effect of vitamin D analogs alone or in combination with 5-FU on tumor growth, life span and body weight of mice bearing subcutaneously MC38 colon cancer

From: Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

Analog (AN) 5-FU AN TGI [%] on the 25th day of the experiment ILS [%] Maximal decrease
in body weight [%]
5-FU AN 5-FU + AN %H TGI Effect 5-FU AN 5-FU + AN %H ILS Effect 5-FU AN 5-FU + AN
PRI-2191 100 mg/kg 0.2 μg/kg 69 42 73 82 Subadditive 63 4 67 64 No effect 4 7 4
PRI-2205 100 mg/kg 20 μg/kg 69 -16 72 64 Synergism 63 0 83 62 Synergism 4 5 1
  1. Vitamin D analog was administered subcutaneously, five times a week.
  2. AN Analog of vitamin D, TGI Tumor growth inhibition, %H TGI Hypothetical tumor growth inhibition, ILS Increase in life span, %H ILS Hypothetical increase in life span, Number of mice: control - 9; PRI-2191 – 7, PRI-2205: 7, 5-FU: 5, 5-FU + PRI-2205: 6, 5-FU + PRI-2191 – 7.
  3. Mice bearing s.c. MC38 colon cancer cells were i.v. injected with 5-FU at a dose of 100 mg/kg/day on days: 2 and 17 and/or vitamin D analogs: PRI-2191 at a dose of 0.2 μg/kg/day or PRI-2205 at a dose of 20 μg/kg/day. Both analogs were administrated s.c., five times a week from days: 9 to 25.