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Table 1 The effect of vitamin D analog PRI-2191 (in varied doses) alone or in combination with 5-FU on tumor growth, life span and body weight of mice bearing subcutaneous colon cancer MC38

From: Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

No. 5-FU PRI-2191 TGI [%] ILS [%] Maximal decrease
in body weight [%]
5-FU PRI-2191 5-FU+ %H TGI Effect 5-FU PRI-2191 5-FU+ %H ILS Effect 5-FU PRI-2191 5-FU+
PRI-2191 PRI-2191 PRI-2191
1 75 mg/kg; 2 μg/kg 48 6 70* 51 Synergism 21 53 41 62 Antagonism 7 18 19
2 150 mg/kg; 2 μg/kg 87 44 96* 92 Synergism nt. nt. nt. nt. nt. 9 11 21
3 100 mg/kg; 1 μg/kg 38 6 51 42 Synergism 26 -6 118*a 22 Synergism 4 6 12
4 100 mg/kg; 0.5 μg/kg 38 1 36 39 Antagonism 26 -6 43 22 Synergism 4 3 9
5 100 mg/kg; 0.25 μg/kg 38 -35 36 16 Antagonism 26 3 65 29 Synergism 4 9 9
  1. Vitamin D analog was administered subcutaneously, three times a week.
  2. No. – number of experiment; TGI – tumor growth inhibition; %H TGI: hypothetical tumor growth inhibition; ILS: increase in life span; %H ILS: hypothetical increase in life span; nt.: not tested; No. 1 – TGI calculated on the 27th day of the experiment, No. 2, 3, 4, 5 – TGI on the 32nd day of the experiment.
  3. No. 1: 5-FU was injected i.p. on the first day; PRI-2191 was injected on days: 1, 3, 6, 8, 10, 13, 15, 17, 20, 22; Number of mice: control - 10; in the each treatment group - 8.
  4. No. 2: 5-FU was injected i.p. on days: 9, 16, 23; PRI-2191 was injected on days: 11, 14, 16, 18, 21, 23; Number of mice in each group - 8.
  5. No. 3, 4 and 5: 5-FU was injected i.v. on days: 8, 15, 30, 38; PRI-2191 was injected on days: 9, 11, 14, 16, 18, 21, 23, 25, 28, 30, 32, 35, 37, 39, 42, 44; Number of mice: No. 3, 4 and 5: control – 7; 5-FU – 7, PRI-2191 – 5; 5-FU + PRI-2191 – 6; * P < 0.05 as compared to control; *a P < 0.05 as compared to 5-FU.