Figure 6

MC38 tumor growth in mice treated with capecitabine (CPC) alone and in combination with vitamin D analogs. A) The kinetics of tumor growth. B) The number of mice with tumors in treated groups during experiment. CPC was administered p.o. at a dose of 450 mg/kg/day and/or vitamin D analogs: PRI-2191 at a dose of 1 μg/kg/day and PRI-2205 at a dose of 10 μg/kg/day, both were administrated s.c., three times a week. Black arrows indicate the days of CPC administration and gray – days of vitamin D analog administration. The number of mice: control - 8; PRI-2191 – 4, PRI-2205: 3, 5-FU: 6, 5-FU + PRI-2191 – 6; 5-FU + PRI-2205: 6. Statistical analysis: Kruskal-Wallis ANOVA Multiple Comparisons P values (2-tailed) test. P < 0.05 as compared to the control: CPC from days 14 to 35; PRI-2191 in combined treatment with CPC from days 10 to 35; PRI-2205 in combined treatment with CPC from days 10 to 33.