The effect of PRI-2191 or PRI-2205 alone or in combination with 5-FU on MC38 tumors transplanted ortotopically. A) Intestinal tumor weight. B) Body weight of mice during treatment. Mice bearing MC38 tumors implanted i.i. were i.v. injected with 5-FU at a dose of 100 mg/kg/day on days 8 and 15 and vitamin D analogs: PRI-2191 at a dose of 1 μg/kg/day or PRI-2205 at a dose of 10 μg/kg/day. Both analogs were administrated s.c., three times a week from days 10 to 20. Mice were sacrificed on the 22nd day after i.i. transplantation, tumors were weighed and blood was collected. Black arrows indicate the days of 5-FU administration, gray – days of vitamin D analogs administration. Number of mice: control - 7; PRI-2191 – 4, PRI-2205: 6, 5-FU: 6, 5-FU + PRI-2191 – 7; 5-FU + PRI-2205: 6; **
P < 0.01 – 5-FU + PRI-2191 compared to control; *
P < 0.05 – 5-FU + PRI-2191 compared to PRI-2191.