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Table 3 BAX mRNA expression and NPC patients’ survival

From: Quantitative expression analysis and prognostic significance of the BCL2-associated Xgene in nasopharyngeal carcinoma: a retrospective cohort study

  Disease-free survival (DFS) Overall survival (OS)
Variable HRa 95% CIb p value HRa 95% CIb p value
  Univariate analysis
BAX mRNA expression       
 Negative 1.00    1.00   
 Positive 0.28 0.13 – 0.62 0.001 0.27 0.12 – 0.59 0.001
Gender (male / female) 1.42 0.66 – 3.09 0.37 1.81 0.79 – 4.18 0.16
Age (≤ 30 years / >30 years) 1.51 0.61 – 3.73 0.37 1.82 0.68 – 4.84 0.23
Tumor histology (undifferentiated / non-keratinizing) 0.59 0.28 – 1.25 0.17 0.72 0.33 – 1.57 0.41
Tumor extent (ordinal) 1.46 1.01 – 2.13 0.046 1.52 1.03 – 2.23 0.034
Regional lymph node status (ordinal) 1.34 0.91 – 1.98 0.14 1.32 0.90 – 1.94 0.16
TNM stage (ordinal) 2.79 1.82 – 4.26 <0.001 1.81 1.31 – 2.48 <0.001
  Multivariate analysis
BAX mRNA expressionc       
 Negative 1.00    1.00   
 Positive 0.35 0.15 – 0.86 0.022 0.33 0.13 – 0.84 0.020
Gender (male / female) 1.26 0.48 – 3.31 0.64 1.66 0.55 – 4.99 0.37
Age (≤ 30 years / >30 years) 1.45 0.53 – 4.01 0.47 1.88 0.59 – 5.95 0.28
Tumor histology (undifferentiated / non-keratinizing) 0.64 0.30 – 1.40 0.27 0.61 0.26 – 1.40 0.24
Tumor extent (ordinal) 1.26 0.76 – 2.06 0.37 1.34 0.79 – 2.29 0.27
Regional lymph node status (ordinal) 1.06 0.70 – 1.60 0.78 1.07 0.68 – 1.70 0.77
BAX mRNA expressiond       
 Negative 1.00    1.00   
 Positive 0.67 0.29 – 1.56 0.35 0.36 0.16 – 0.84 0.018
Gender (male / female) 0.78 0.35 – 1.76 0.55 1.20 0.46 – 3.08 0.71
Age (≤ 30 years / >30 years) 1.68 0.66 – 4.31 0.28 2.18 0.76 – 6.24 0.15
Histology (undifferentiated / non-keratinizing) 0.95 0.43 – 2.12 0.90 0.64 0.27 – 1.50 0.30
TNM stage 2.60 1.68 – 4.04 <0.001 1.76 1.25 – 2.46 0.001
  1. aHazard ratio (HR), estimated from Cox proportional hazard regression model.
  2. bConfidence interval of the estimated HR.
  3. cMultivariate models were adjusted for gender, age, tumor histology, tumor extent, and regional lymph node status.
  4. dMultivariate models were adjusted for gender, age, tumor histology, and TNM stage.