Figure 7

MiR-204 activates LKB1 by repressing SIRT1expression. (A) Western blot analysis showed the level of the endogenous LKB1 protein in AGS and BCG cells that were transfected with SIRT1 SiRNA. (B) Western blot analysis showed the level of endogenous LKB1 protein in AGS and BCG cells that were transfected with miR-204. (C) Inhibition of LKB1 could sabotage the miR-204 induced-cancer cell migration reduction. The profiles are representative of at least three independent experiments. N.C, negative control. *P < 0.05, **P<0.01.