Table 1 Percentage of H-460 cells in late or early apoptosis at the end of treatment period either with doxorubicin or P276-00 alone or in the combination of doxorubicin followed by P276-00
Treatment group | Percentage of cells | |||
|---|---|---|---|---|
Live cells | Annexin +ve | Annexin + PI | PI +ve | |
Control | 90.5 | 3 | 4 | 2.3 |
Doxorubicin ( 100 nM) | 60 | 30.4 | 8.6 | 1 |
P276-00 (1200 nM) | 53 | 38.5 | 8.2 | 0.3 |
Doxorubicin> P276-00 | 14.1 | 50.2 | 34.3 | 2 |