Figure 3

SAHA induces pro-proliferative programs. A–C. Microarrays were performed after treatment of rhabdoid tumor cell line A204 for 12 h with HDAC inhibitor SAHA. Gene set enrichment analysis (GSEA) [23, 24] demonstrate that gene sets of MYC (A), Rb associated (B) and stem cell associated (C) are positively enriched in SAHA-treated rhabdoid tumor cell line A204. Genes on the X-axis show the overlap between the defined gene set and the regulated genes in the experiment. NES- negative enrichment score; FDR- false discovery rate (for brief description of statistics see http://www.broadinstitute.org/gsea/doc/GSEAUserGuideFrame.html).