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Figure 1 | BMC Cancer

Figure 1

From: The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

Figure 1

Expression of HDACs in rhabdoid tumors. A and B. HDACs are highly expressed on RNA level in primary rhabdoid tumors (n = 23) in comparison to differentiated brain tissue (n = 169) using available gene expression profiles of AT/RT [24] and different normal brain tissues [26]. C. HDAC1 and HDAC2 are highly expressed in mouse embryonic stem cells (ESC cell line OG2) and are down regulated after five days of differentiation (without LIF). D. Western-Blots of SMARCB1 negative rhabdoid tumor cell lines (BT12, BT16, A204, G401) show high expression of HDAC 1 and HDAC 2, which is comparable to the expression of these HDACs in embryonal stem cells (OG2).

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